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Engineering Immune Cell to Counteract Aging and Aging-Associated Diseases
Jianhua Guo1, Lanjie Lei1, Ying Jin2
1Key lab of Artificial Organs and Computational Medicine, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, China.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 28, 2026
Summary
Cellular immunotherapies show promise for combating aging by leveraging the immune system to clear senescent cells and reduce inflammation. Future advancements aim to personalize these anti-aging treatments for extended healthspan.
Area of Science:
- Immunology
- Gerontology
- Biotechnology
Background:
- Aging and associated diseases pose significant public health challenges.
- Current anti-aging strategies using small molecules have limited clinical success.
- Cellular immunotherapies, particularly chimeric antigen receptor (CAR)-engineered cells, show potential beyond cancer treatment.
Purpose of the Study:
- To review the immune system's role in counteracting aging.
- To synthesize principles of immune cell-based anti-aging therapies.
- To analyze current preclinical and clinical studies in this field.
Main Methods:
- Review of scientific literature on immune system function in aging.
- Analysis of preclinical and clinical studies of cellular immunotherapies for aging.
- Synthesis of challenges and future directions in the field.
Main Results:
- The immune system naturally clears senescent cells, reduces inflammation, and promotes regeneration.
- Cellular immunotherapies offer a novel approach to modulating aging processes.
- Key challenges include target specificity, immunosuppressive environments, and cell variability.
Conclusions:
- Cellular immunotherapies hold transformative potential for modulating aging and extending healthspan.
- Multidisciplinary collaboration and technologies like AI are crucial for personalized anti-aging interventions.
- This approach aligns with the advancement of precision medicine.
Keywords:
agingaging‐associated pathologiescellular immunotherapiesclinical translationmechanism explorationMore Related Videos
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