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Updated: Jan 29, 2026

Modeling Age-Associated Neurodegenerative Diseases in Caenorhabditis elegans
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Engineering Immune Cell to Counteract Aging and Aging-Associated Diseases

Jianhua Guo1, Lanjie Lei1, Ying Jin2

  • 1Key lab of Artificial Organs and Computational Medicine, Institute of Translational Medicine, Zhejiang Shuren University, Hangzhou, Zhejiang, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|January 28, 2026
PubMed

Insights

Cellular immunotherapies show promise for combating aging by leveraging the immune system to clear senescent cells and reduce inflammation. Future advancements aim to personalize these anti-aging treatments for extended healthspan.

Area of Science:

  • Immunology
  • Gerontology
  • Biotechnology

Background:

  • Aging and associated diseases pose significant public health challenges.
  • Current anti-aging strategies using small molecules have limited clinical success.
  • Cellular immunotherapies, particularly chimeric antigen receptor (CAR)-engineered cells, show potential beyond cancer treatment.

Purpose of the Study:

  • To review the immune system's role in counteracting aging.
  • To synthesize principles of immune cell-based anti-aging therapies.
  • To analyze current preclinical and clinical studies in this field.

Main Methods:

  • Review of scientific literature on immune system function in aging.
  • Analysis of preclinical and clinical studies of cellular immunotherapies for aging.
  • Synthesis of challenges and future directions in the field.

Main Results:

  • The immune system naturally clears senescent cells, reduces inflammation, and promotes regeneration.
  • Cellular immunotherapies offer a novel approach to modulating aging processes.
  • Key challenges include target specificity, immunosuppressive environments, and cell variability.

Conclusions:

  • Cellular immunotherapies hold transformative potential for modulating aging and extending healthspan.
  • Multidisciplinary collaboration and technologies like AI are crucial for personalized anti-aging interventions.
  • This approach aligns with the advancement of precision medicine.
Keywords:
agingaging‐associated pathologiescellular immunotherapiesclinical translationmechanism exploration

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