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Innovative Metasurface Colorimetric Cell-on-a-Chip Sensor for Continuous, Label-Free, Non-Destructive Assessment of

Youqian Chen1,2, Wen Li2, Jiaying Feng1

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Summary

This study introduces a novel sensor for real-time, non-destructive assessment of intestinal barrier function in cell-on-a-chip models, improving disease study and drug development.

Keywords:
MetaSPR biosensoraffinity detectioncell‐on‐a‐chipintestinal cell barrierlive‐cell imagingreal‐time cell monitoring

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Drug Development

Background:

  • Assessing intestinal barrier function is vital for disease research and drug development.
  • Current methods lack continuous, non-destructive monitoring capabilities for intestinal barrier dynamics.

Purpose of the Study:

  • To develop a real-time, label-free, high-throughput cell-on-a-chip system for evaluating intestinal barrier function.
  • To enable non-destructive monitoring of intestinal barrier dynamics.

Main Methods:

  • Development of a metasurface plasmon resonance colorimetric sensor (MetaSPRCS) integrated with transmission microscopy.
  • Utilizing the MetaSPRCS platform for real-time visualization of cellular processes and barrier integrity.
  • Assessing epithelial cell damage and evaluating therapeutic compounds like Dihydroquercetin (DHQ).

Main Results:

  • The MetaSPRCS system provides real-time visualization of cell adhesion, proliferation, and barrier formation/disruption/repair.
  • The platform demonstrated higher sensitivity in detecting epithelial cell damage compared to CCK-8 assays.
  • MetaSPRCS successfully validated DHQ efficacy in an alcohol-induced injury model and predicted in vitro-to-in vivo dose conversion.

Conclusions:

  • The developed MetaSPRCS tool offers a high-throughput, visual, and non-destructive method for assessing intestinal homeostasis.
  • This technology provides a preliminary dose conversion relationship between in vitro and in vivo experiments for novel ingredients.
  • The system holds promise for advancing intestinal disease research and drug development.