Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glycocalyx and its Functions01:14

Glycocalyx and its Functions

8.3K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
8.3K
Enzymes02:34

Enzymes

94.6K
Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
94.6K
Enzyme Kinetics01:19

Enzyme Kinetics

104.0K
Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
104.0K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.0K
Overview
80.0K
Resistivity01:22

Resistivity

4.5K
When a voltage is applied to a conductor, an electrical field is generated, and charges in the conductor feel the force due to the electrical field. The current density that results depends on the electrical field and the properties of the material. In some materials, including metals at a given temperature, the current density is approximately proportional to the electrical field. In these cases, the current density can be modeled as:
4.5K
Resistance01:19

Resistance

5.9K
When a current moves through any conductor, the conductor causes some level of difficulty for the current to flow. The measure of that difficulty is known as the resistance of the material and is represented by R. Every material has its own resistance. In the case of conductors, heat is emitted whenever a current passes through them. Resistance depends on the resistivity of the material. Resistivity is a characteristic of the material used to fabricate electrical components, whereas the...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development and Validation of a Machine Learning-Based Individualized Model to Predict TKI Benefit in Postoperative Recurrent HCC.

Journal of hepatocellular carcinoma·2026
Same author

Uric acid influences the relationship between unsafe neighborhood and digestive diseases among middle-aged or older adults: a longitudinal cohort study from the China Health and Retirement Longitudinal Study (CHARLS).

BMC public health·2026
Same author

Comparison of XEN gel stent for management of open-angle glaucoma: a systematic review and meta-analysis.

PeerJ·2026
Same author

A Modified Capsular Hook Implantation Technique for IOL-Capsular Bag Complex Subluxation: Clinical Outcomes From a Comparative Study.

Journal of refractive surgery (Thorofare, N.J. : 1995)·2026
Same author

A metal-organic framework-based trilayer biomimetic coating on lacrimal stents for dual-drug therapy to prevent restenosis.

Acta biomaterialia·2026
Same author

Fatty acid β-oxidation-associated prognostic model in gastric cancer and functional validation of IL-6 as a potential therapeutic target.

Scientific reports·2026
Same journal

Oxygen-Independent Supramolecular Nanoplatform for Photothermal-Thermodynamic Therapy against Periodontal Anaerobic Infections.

Advanced healthcare materials·2026
Same journal

An All-in-One Nanoplatform for Synergistic Anti-Infection and Healing of Diabetic Wounds via Photothermal-Gas Therapy.

Advanced healthcare materials·2026
Same journal

Bioactive Hydrogels with D-Amino Acid RGD Mimics: A Therapeutic Strategy for Expeditious Infected Wound Closure.

Advanced healthcare materials·2026
Same journal

An Asymmetric Dura-Inspired Collagen Hydrogel Patch with Integrated Dense-Porous Architecture Enabled by Dual-Channel Freeze Casting.

Advanced healthcare materials·2026
Same journal

Pathology-Targeted Nanoparticles Guided by Peptide Remodel the Periodontal Microenvironment for Periodontitis Therapy.

Advanced healthcare materials·2026
Same journal

Gellan Gum Fluid Gel System for Controlled-Delivery of Cytokine-Licensed MSC-EVs to Enhance Corneal Repair in Limbal Stem Cell Deficiency.

Advanced healthcare materials·2026
See all related articles

Related Experiment Video

Updated: Jan 29, 2026

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy
10:24

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy

Published on: February 21, 2013

13.6K

Enzyme-Resistant Glycocalyx Bionic Coating for Corneal Bandage Lens Surface Engineering.

Zezhen Zhang1, Xiao Chen2,3, Shimeng Zhang1

  • 1The Department of Ophthalmology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Advanced Healthcare Materials
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

This study introduces an enzyme-resistant glycocalyx bionic coating (ER-GBC) for medical devices. The novel coating enhances functionality and therapeutic outcomes in corneal injury treatment.

Keywords:
corneal bandage lensenzyme‐resistantglycocalyx bionic coatinghyaluronic acidkeratitis

More Related Videos

The Bionic Clicker Mark I & II
08:23

The Bionic Clicker Mark I & II

Published on: August 14, 2017

16.7K
Protein Engineering by Yeast Surface Display
05:49

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

3.5K

Related Experiment Videos

Last Updated: Jan 29, 2026

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy
10:24

Quantifying the Mechanical Properties of the Endothelial Glycocalyx with Atomic Force Microscopy

Published on: February 21, 2013

13.6K
The Bionic Clicker Mark I & II
08:23

The Bionic Clicker Mark I & II

Published on: August 14, 2017

16.7K
Protein Engineering by Yeast Surface Display
05:49

Protein Engineering by Yeast Surface Display

Published on: November 29, 2024

3.5K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Advanced implantable medical devices require multifunctional surfaces for in vivo applications.
  • Glycocalyx bionic coatings mimic natural barriers but are susceptible to enzymatic degradation.
  • Corneal bandage lenses (CBLs) for injury treatment face challenges from bio-enzymes degrading natural polymer coatings.

Purpose of the Study:

  • To develop an enzyme-resistant glycocalyx bionic coating (ER-GBC) strategy.
  • To enhance the stability and functionality of bionic coatings for medical devices.
  • To improve therapeutic outcomes for corneal injuries using modified CBLs.

Main Methods:

  • Incorporated baicalin as a hyaluronidase inhibitor into hyaluronic acid-based glycocalyx bionic coatings (GBCs).
  • Utilized baicalin's antioxidant and bacteriostatic properties, alongside silver nanoparticles' bactericidal effects.
  • Developed a multifunctional ER-GBC with hydrophilic, anti-bacterial, and anti-inflammatory properties.

Main Results:

  • The baicalin-infused GBC demonstrated resistance to hyaluronidase degradation.
  • The ER-GBC exhibited enhanced anti-bacterial and anti-inflammatory capabilities.
  • ER-GBC-modified CBLs showed significant therapeutic efficacy in a rabbit model of bacterial keratitis.

Conclusions:

  • The ER-GBC strategy effectively overcomes enzymatic degradation issues in bionic coatings.
  • Combining glycocalyx components with enzyme inhibitors offers a novel approach for medical device coatings.
  • This strategy holds promise for developing advanced bionic coatings for clinical translation.