Enzyme-Resistant Glycocalyx Bionic Coating for Corneal Bandage Lens Surface Engineering

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Nanotechnology

Background:

• Advanced implantable medical devices require multifunctional surfaces for in vivo applications.
• Glycocalyx bionic coatings mimic natural barriers but are susceptible to enzymatic degradation.
• Corneal bandage lenses (CBLs) for injury treatment face challenges from bio-enzymes degrading natural polymer coatings.

Purpose of the Study:

• To develop an enzyme-resistant glycocalyx bionic coating (ER-GBC) strategy.
• To enhance the stability and functionality of bionic coatings for medical devices.
• To improve therapeutic outcomes for corneal injuries using modified CBLs.

Main Methods:

• Incorporated baicalin as a hyaluronidase inhibitor into hyaluronic acid-based glycocalyx bionic coatings (GBCs).
• Utilized baicalin's antioxidant and bacteriostatic properties, alongside silver nanoparticles' bactericidal effects.
• Developed a multifunctional ER-GBC with hydrophilic, anti-bacterial, and anti-inflammatory properties.

Main Results:

• The baicalin-infused GBC demonstrated resistance to hyaluronidase degradation.
• The ER-GBC exhibited enhanced anti-bacterial and anti-inflammatory capabilities.
• ER-GBC-modified CBLs showed significant therapeutic efficacy in a rabbit model of bacterial keratitis.

Conclusions:

• The ER-GBC strategy effectively overcomes enzymatic degradation issues in bionic coatings.
• Combining glycocalyx components with enzyme inhibitors offers a novel approach for medical device coatings.
• This strategy holds promise for developing advanced bionic coatings for clinical translation.