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Related Concept Videos

Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

10.7K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
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Non-gated Ion Channels01:24

Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
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Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.7K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.7K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

14.3K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
14.3K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

5.7K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
5.7K
Ligand-Gated Ion Channel Receptor: Gating Mechanism01:30

Ligand-Gated Ion Channel Receptor: Gating Mechanism

3.9K
Ligand-gated ion channels are transmembrane proteins that play a vital role in intercellular communication and functions of the nervous system. They allow the influx of ions across the membrane once the neurotransmitter binds, allowing the subsequent transmission of electrical excitation across the neurons. Other ligand-gated ion channels, like the γ-aminobutyric acid (GABA) receptor, permit anions like chloride into the cells on the binding of the GABA molecule. Their entry into the cell...
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Related Experiment Video

Updated: Jan 29, 2026

Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells
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Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells

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NavDB: A Comprehensive Database for Voltage-Gated Sodium Channels Modulators and Targets.

Gaoang Wang1, Jiahui Yu2, Haiyi Chen3

  • 1Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, Zhejiang 310058, China.

Journal of Chemical Information and Modeling
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

NavDB is a new database for voltage-gated sodium channel (VGSC) modulators. It consolidates information on compounds and targets, including peptides, to aid drug discovery.

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Area of Science:

  • Pharmacology
  • Biochemistry
  • Computational Biology

Background:

  • Voltage-gated sodium channels (VGSCs) are crucial therapeutic targets for neurological, muscular, and cardiac conditions.
  • Existing databases lack comprehensive and consistent information on VGSC modulators, especially peptides.

Purpose of the Study:

  • To develop NavDB, a specialized, open-access database for VGSC modulators and targets.
  • To address the limitations of current databases by integrating diverse compound types and providing advanced search functionalities.

Main Methods:

  • Curated 8023 data records on 5168 compounds (small molecules, toxins, drugs, peptides).
  • Integrated comprehensive annotations on biological activity, druggability, and structural features.
  • Developed advanced search (text, structure, peptide similarity) and AI-powered property prediction.

Main Results:

  • NavDB provides integrated data on VGSC modulators and targets.
  • Includes 3D visualizations, disulfide bond, and signal peptide annotations.
  • Offers freely downloadable data to support drug discovery.

Conclusions:

  • NavDB serves as a valuable resource for researchers in VGSC-related drug discovery.
  • The database facilitates both experimental and computational approaches by providing comprehensive and accessible data.