NavDB: A Comprehensive Database for Voltage-Gated Sodium Channels Modulators and Targets.
Gaoang Wang1, Jiahui Yu2, Haiyi Chen3
1Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, Hangzhou, Zhejiang 310058, China.
Journal of Chemical Information and Modeling
|January 28, 2026
Summary
NavDB is a new database for voltage-gated sodium channel (VGSC) modulators. It consolidates information on compounds and targets, including peptides, to aid drug discovery.
Area of Science:
- Pharmacology
- Biochemistry
- Computational Biology
Background:
- Voltage-gated sodium channels (VGSCs) are crucial therapeutic targets for neurological, muscular, and cardiac conditions.
- Existing databases lack comprehensive and consistent information on VGSC modulators, especially peptides.
Purpose of the Study:
- To develop NavDB, a specialized, open-access database for VGSC modulators and targets.
- To address the limitations of current databases by integrating diverse compound types and providing advanced search functionalities.
Main Methods:
- Curated 8023 data records on 5168 compounds (small molecules, toxins, drugs, peptides).
- Integrated comprehensive annotations on biological activity, druggability, and structural features.
- Developed advanced search (text, structure, peptide similarity) and AI-powered property prediction.
Main Results:
- NavDB provides integrated data on VGSC modulators and targets.
- Includes 3D visualizations, disulfide bond, and signal peptide annotations.
- Offers freely downloadable data to support drug discovery.
Conclusions:
- NavDB serves as a valuable resource for researchers in VGSC-related drug discovery.
- The database facilitates both experimental and computational approaches by providing comprehensive and accessible data.
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