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Updated: Jan 29, 2026

Author Spotlight: Metallic Nanocomposites to Eliminate Antibiotic-Resistant Bacteria
Published on: October 4, 2024
Recent Progress in Organic Small-Molecule Antibacterial Agents
Xiaoran Huang1, Yingying Meng1,2, Peirong Zhou1
1Institute of Polymer Optoelectronic Materials and Devices, Guangdong Basic Research Center of Excellence for Energy & Information Polymer Materials, State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, School of Materials Science and Engineering, South China University of Technology, Guangzhou, China.
Abstract:
Antibiotic resistance has become a critical global threat, creating an urgent need for new antibacterial agents. Among therapeutic modalities, small-molecule antibacterials offer significant advantages, including controllable metabolism and flexible structural design, making them an excellent platform for combating drug-resistant bacteria. This review highlights recent progress in organic small-molecule antibacterials and is organized into three sections: antibiotics, natural products and their derivatives, and other synthetic small-molecule agents (including heterocyclic, sulfonamide, and amphiphilic compounds). Each section summarizes recent advances in the field, and the review concludes by discussing future directions and challenges in small-molecule antibiotic development. By drawing on strategies across these categories, this overview provides researchers in the field with a fresh perspective to inspire novel approaches and accelerate the development of new antibacterial drugs.
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