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Updated: Jan 30, 2026

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

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Published on: June 12, 2011

Multifunctional Ultrasound Microbubbles.

Roman A Barmin¹, Mirjavad Moosavifar¹, Andreas Herrmann^2,3

¹Institute for Experimental Molecular Imaging, RWTH Aachen University Hospital, 52074 Aachen, Germany.

Chemical Reviews

|January 28, 2026

Summary

This summary is machine-generated.

Multifunctional microbubbles (MBs) are advancing beyond diagnostics for targeted therapies like drug delivery and thrombolysis. These versatile agents offer enhanced imaging and therapeutic potential for unmet medical needs.

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Published on: February 5, 2022

Area of Science:

Biomedical Engineering
Nanotechnology
Medical Imaging

Background:

Microbubbles (MBs) are established ultrasound (US) contrast agents for cardiac and liver imaging.
Molecularly targeted MBs are in clinical trials for oncological and inflammatory diseases.
MBs are emerging as therapeutic tools for drug delivery, blood-brain barrier permeation, and thrombolysis.

Purpose of the Study:

To review and critically assess advances in multifunctional MBs for biomedical applications.
To provide an overview of MB formulations, functional agents, and conjugation strategies.
To evaluate current trends and challenges in the clinical translation of multifunctional MBs.

Main Methods:

Comprehensive literature review of multifunctional microbubble formulations.
Analysis of incorporated functional agents (small molecules, nanomaterials, targeting ligands).
Evaluation of conjugation and functionalization strategies for next-generation MBs.

Main Results:

Multifunctional MBs integrate diagnostic and therapeutic capabilities.
Loading MBs with magnetic or optical agents enables multimodal imaging (MRI, photoacoustic).
Functionalized MBs show potential for targeted drug delivery and thrombolysis.

Conclusions:

Multifunctional MBs address biomedical needs beyond conventional agents.
These advanced MBs hold significant promise for future diagnostic and therapeutic applications.
Further research and clinical translation are crucial for realizing the full potential of next-generation MBs.