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Updated: Jan 30, 2026
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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
Published on: August 28, 2015
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Functionalization of carbon nano-onions for potential biomedical applications
Mariana Prodana1, Daniela Ionita2, Calin C Moise3
1Department of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology POLITEHNICA Bucharest, 313 Splaiul Independentei, Bucharest 060042, Romania; Center for Surface Science and Nanotechnology, National University of Science and Technology POLITEHNICA Bucharest, 313 Splaiul Independentei, Bucharest 060042, Romania.
Summary
We synthesized carbon nano-onions (CNOs) and functionalized them with cisplatin for biomedical applications. This hybrid approach enhances CNOs
Area of Science:
- Nanotechnology and Materials Science
- Biomedical Engineering
Background:
- Carbon nano-onions (CNOs), a less-explored allotrope of carbon, offer unique structural properties.
- Functionalization of nanomaterials is crucial for improving solubility, biocompatibility, and cellular uptake in biomedical applications.
Purpose of the Study:
- To synthesize in-house carbon nano-onions (CNOs) using pulsed laser ablation.
- To develop a hybrid functionalization method involving carboxylic groups and cisplatin adsorption onto CNOs.
- To explore the potential of platinum-oxidizing nano-onions for biomedical applications.
Main Methods:
- Synthesis of CNOs via pulsed laser ablation.
- Functionalization of CNOs with carboxylic groups followed by cisplatin adsorption.
- Characterization using micro-Raman spectroscopy, FTIR, and HR-STEM with Energy-Dispersive X-ray spectroscopy.
- Quantification of platinum ion release using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).
Main Results:
- Successful synthesis of CNOs and their subsequent functionalization with carboxylic groups and cisplatin.
- Demonstration of platinum-oxidizing nano-onions, indicating successful cisplatin adsorption.
- Characterization confirmed the chemical composition, molecular structure, and morphology of the functionalized CNOs.
Conclusions:
- The developed hybrid functionalization method is effective for preparing platinum-loaded CNOs.
- Functionalized CNOs show promise for enhanced solubility and biocompatibility, facilitating cellular penetration.
- These platinum-oxidizing nano-onions hold potential for future biomedical applications.
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