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In vivo Doppler holography of the optic nerve head in glaucoma: Response to acute IOP decrease.

R Lecoge1, P Bastelica2, M Atlan3

  • 1Department of Ophthalmology, Ambroise-Paré Hospital, AP-HP, Boulogne-Billancourt, France; Université Versailles Saint-Quentin en Yvelines, Versailles, France.

Journal Francais D'Ophtalmologie
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

Lowering intraocular pressure (IOP) in primary open-angle glaucoma (POAG) patients significantly improved diastolic blood flow in the central retinal artery (CRA). Doppler holography accurately measured these changes in CRA blood flow.

Keywords:
Artère centrale de la rétineBlood flow velocityCentral retinal arteryDoppler holographyGlaucome primitif à angle ouvertHolographie DopplerPrimary open angle glaucomaVitesse du flux sanguin

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Area of Science:

  • Ophthalmology
  • Medical Imaging
  • Cardiovascular Research

Background:

  • Doppler holography offers non-invasive imaging of retinal blood flow.
  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Understanding the impact of intraocular pressure (IOP) on optic nerve head blood flow is crucial in POAG management.

Purpose of the Study:

  • To investigate the effect of reducing intraocular pressure (IOP) on central retinal artery (CRA) blood flow.
  • To evaluate the utility of Doppler holography in measuring these hemodynamic changes.
  • To assess the relationship between IOP reduction and blood flow parameters in POAG patients.

Main Methods:

  • Four patients with POAG and elevated IOP were enrolled.
  • Doppler holography was used to measure CRA blood flow velocity before and after surgical IOP reduction.
  • Key parameters calculated included peak systolic velocity (PSV), end diastolic velocity (EDV), resistivity index (RI), and area under the velocity curve (AUC).

Main Results:

  • A median IOP decrease of 23mmHg was achieved post-surgery.
  • Significant improvements were observed in diastolic CRA flow (EDV increased, P=0.029) and RI (decreased, P=0.029).
  • Systolic flow (PSV) and the area under the velocity curve (AUC) did not show significant changes.

Conclusions:

  • Surgical reduction of IOP in POAG patients leads to improved diastolic blood flow in the CRA.
  • Doppler holography is a precise tool for quantifying CRA blood flow dynamics.
  • These findings highlight the importance of IOP control for maintaining ocular blood perfusion in glaucoma.