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Updated: Jan 30, 2026
08:03
Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents
Published on: June 6, 2018
15.1K
Predictors of successful erectile function using intracavernosal injection in post-prostatectomy men with erectile
Yotam Veredgorn1, Ziv Savin2, Ron Marom1
1Department of Urology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Summary
Intracavernosal injections (ICI) effectively treat erectile dysfunction post-radical prostatectomy (RP) in men resistant to PDE5 inhibitors. Persistent urinary incontinence predicts a poorer response to ICI therapy.
Area of Science:
- Urology
- Andrology
- Sexual Medicine
Background:
- Intracavernosal injections (ICI) are a common treatment for erectile dysfunction (ED) after radical prostatectomy (RP).
- Predictors of successful ICI treatment outcomes remain incompletely understood.
- This study investigates clinical and pathological factors influencing erectile function recovery with ICI post-RP.
Purpose of the Study:
- To identify predictors of successful erectile function using intracavernosal injections (ICI) in men following radical prostatectomy (RP).
- To explore the relationship between patient parameters and satisfactory erections achieved with ICI therapy.
Main Methods:
- Prospective study of men with ED post-RP, unresponsive to PDE5 inhibitors (PDE5I).
- Utilized escalating dosages of TRIMIX (papaverine, phentolamine, alprostadil).
- Assessed erectile function using the Erection Hardness Scale (EHS) and International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF).
Main Results:
- 85% of patients (29/34) achieved satisfactory erectile function with ICI.
- ICIQ-SF scores significantly correlated with erectile response (p=0.001).
- Higher ICIQ-SF scores were associated with partial or non-response (OR 1.3, p=0.002).
Conclusions:
- Intracavernosal injections (ICI) represent an effective treatment for erectile dysfunction in men post-RP who are resistant to PDE5 inhibitors.
- Sustainable urinary incontinence is a significant predictor of suboptimal response to ICI therapy.
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