[Research status and prospect of orthodontically induced inflammatory root resorption]

Orthodontically induced inflammatory root resorption (OIIRR) is one of the most common and troublesome complications in orthodontic treatment, which not only affects the long-term stability of teeth, but also can cause irreversible damage to the patient's oral health. In light of the rising demand for orthodontic treatment, the prevention and treatment of OIIRR has become a primary focus for clinicians and researchers. Recent multidisciplinary studies have revealed the complex regulatory network of OIIRR, including mechanical signal transduction, immune microenvironment remodelling, cell differentiation pattern transformation and hard tissue matrix-specific regulation. Concurrently, targeted intervention strategies that have been developed based on these mechanisms have demonstrated favourable clinical application prospects. The present article systematically reviewed the clinical characteristics, influencing factors, molecular mechanisms and the latest clinical intervention strategies of OIIRR.