Related Experiment Video
Updated: Jan 30, 2026

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
Published on: August 13, 2019
Effect of Astragalus sinicus Ethanol Extract on Menopausal Symptoms in an Ovariectomized (OVX) Mouse Model
Holim Jin1, Yongjin Lee2, Yoon-A Shin1
1Department of Pharmacy, Sunchon National University, Suncheon 57922, Republic of Korea.
Abstract:
As the aging population grows, the proportion of postmenopausal women is also increasing. Menopause can cause various symptoms and reduce quality of life. Hormone replacement therapy (HRT) is a common treatment to alleviate these symptoms, but long-term use carries the risk of side effects such as breast cancer and endometriosis, highlighting the need for new alternatives. Astragalus sinicus is a plant native to East Asia, primarily used to improve rice cultivation in paddies. However, research on its potential as a medicinal resource remains limited. Therefore, this study aimed to evaluate the potential of A. sinicus ethanol extract as a treatment for menopause-related symptoms using the MCF-7 breast cancer cell line and ovariectomized (OVX) mice. In vitro experiments confirmed that A. sinicus ethanol extract improved the mRNA expression of menopause-related genes and exhibited estrogenic activity. Additionally, in vivo experiments demonstrated that A. sinicus ethanol extract effectively alleviated menopausal symptoms. These findings suggest that A. sinicus ethanol extract may serve as a novel alternative for addressing menopause-related health issues.
Related Concept Videos
Menopause
Diabetes: Symptoms, Diagnosis, and Complications
Negative and Cognitive Symptoms of Schizophrenia
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Asthma-III: Symptoms and Complications
Classification of Asthma
Pleural Effusion II: Symptoms and Management
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
Positive Symptoms Schizophrenia: Hallucinations and Delusions
Hallucinations
Hallucinations in...

