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Updated: Jan 30, 2026

Preparation of DNA-crosslinked Polyacrylamide Hydrogels
Published on: August 27, 2014
Rubber-like DNA hydrogel enabled by fast-shrinking-induced entanglement
Zi'an Lin1, Shuran Fang1, Qingshan Huang1
1Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, State Key Laboratory of Materials Processing and Die & Mould Technology, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), 1037 Luoyu Road, Wuhan, China.
None:
Biomass DNA holds immense potential as a sustainable material, but the scalable production of robust DNA materials with sufficient mechanical strength remains an essential challenge. Herein, we report a Fast-Shrinking-Induced Entanglement (FaSIE) process to achieve rubber-like hydrogels solely composed of DNA (stiffness >800 kPa, toughness >5 MJ/m3, and stretchability > 1000%). Fast shrinking kinetic restricts the chain relaxation, while the ultra-long chain feature of biomass DNA further suppress chain reptation. This synergistic effect enables substantial enhancement of entanglement density, exceeding the threshold required for high mechanical strength. We highlight the broad applicability of this strategy for high-resolution 3D printing of mechanically robust DNA hydrogels and the fabrication of DNA based soft magnetic robots. This approach paves the way for the large-scale production of resilient hydrogel materials derived from biomass DNA for versatile applications.
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