Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cytoplasm01:16

Cytoplasm

88.6K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
88.6K
Cytoplasm01:24

Cytoplasm

8.3K
The cytoplasm consists of organelles and a framework of protein scaffolds called the cytoskeleton suspended in an aqueous solution, the cytosol. The cytosol is a rich broth of water, ions, salts, and various organic molecules.
Protein Folding and Misfolding
The cytoplasm is the location for several cellular processes, including protein synthesis and folding. The aqueous nature of the cytosol promotes protein folding such that the hydrophobic amino acid side chains are buried in the protein...
8.3K
Microtubule Instability02:17

Microtubule Instability

6.2K
Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated...
6.2K
Extraction: Partition and Distribution Coefficients01:14

Extraction: Partition and Distribution Coefficients

4.7K
The distribution law or Nernst's distribution law is the law that governs the distribution of a solute between two immiscible solvents. This law, also known as the partition law, states that if a solute is added to the mixture of two immiscible solvents at a constant temperature, the solute is distributed between the two solvents in such a way that the ratio of solute concentrations in the solvents remains constant at equilibrium.
For extracting a solute from an aqueous phase into an...
4.7K
Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

6.0K
The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
6.0K
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

27.9K
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
27.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manipulating CD38 ectoenzymatic activity revitalizes regulatory T cells via deacetylase Sirt-1 in immune thrombocytopenia.

Journal of thrombosis and haemostasis : JTH·2026
Same author

Comparison of RNA Extraction Method for Human Whole Blood: Assessing the Quality, Quantity, and Impact of RBC Lysis Across TRIzol, Invitrogen, and Qiagen Systems.

Drug testing and analysis·2026
Same author

Chaperone-mediated autophagy reprograms heterogeneous subsets of activated macrophages in immune thrombocytopenia.

Autophagy·2026
Same author

Zebrafish knock-in lines enabling live visualization of extracellular matrix dynamics during development and regeneration.

Development (Cambridge, England)·2026
Same author

A dual-gate organic photoelectrochemical transistor with balanced photoanode voltage for ultrasensitive detection of miRNA-141.

Biosensors & bioelectronics·2026
Same author

Author Correction: A mechanical ratchet drives unilateral cytokinesis.

Nature·2026

Related Experiment Video

Updated: Jan 30, 2026

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
11:11

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins

Published on: June 15, 2018

8.7K

Robust cytoplasmic partitioning by solving a cytoskeletal instability.

Melissa Rinaldin1,2, Alison Kickuth3,4, Adam Lamson3

  • 1Cluster of Excellence Physics of Life, TU Dresden, Dresden, Germany. melissa.rinaldin@tu-dresden.de.

Nature
|January 28, 2026
PubMed
Summary

Embryos use microtubule cytoskeleton dynamics to organize cytoplasm. They employ cell-cycle timing or limited microtubule nucleation to manage cytoskeletal instability, ensuring robust cell division.

More Related Videos

Magnetically Induced Rotating Rayleigh-Taylor Instability
06:42

Magnetically Induced Rotating Rayleigh-Taylor Instability

Published on: March 3, 2017

10.1K
Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
07:42

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

Published on: June 29, 2011

17.8K

Related Experiment Videos

Last Updated: Jan 30, 2026

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins
11:11

Determination of Plasma Membrane Partitioning for Peripherally-associated Proteins

Published on: June 15, 2018

8.7K
Magnetically Induced Rotating Rayleigh-Taylor Instability
06:42

Magnetically Induced Rotating Rayleigh-Taylor Instability

Published on: March 3, 2017

10.1K
Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c
07:42

Activation of Apoptosis by Cytoplasmic Microinjection of Cytochrome c

Published on: June 29, 2011

17.8K

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Biophysics

Background:

  • Early embryonic development requires precise cytoplasmic organization into cells.
  • Microtubule structures are crucial for partitioning cytoplasm during cell division.
  • Embryonic development exhibits robustness despite underlying physical instabilities.

Purpose of the Study:

  • To investigate the intrinsic instability in cytoplasmic partitioning driven by the microtubule cytoskeleton.
  • To identify mechanisms embryos use to circumvent this instability.
  • To understand how species-specific strategies for cytoplasmic organization evolved.

Main Methods:

  • Experiments conducted in cytoplasmic extract and in vivo.
  • Analysis of microtubule dynamics and cell-cycle duration.
  • Comparative studies in zebrafish and Drosophila embryos.

Main Results:

  • Discovered an intrinsic instability in microtubule-driven cytoplasmic partitioning.
  • Identified two distinct embryonic strategies: matching cell-cycle duration or limiting microtubule nucleation.
  • Demonstrated species-specific cytoplasmic filling strategies in zebrafish (unstable waves) and Drosophila (stable asters).

Conclusions:

  • Temporal control of microtubule dynamics drives species-specific cytoplasmic organization.
  • Embryos utilize a synergy between physical instabilities and biological clocks for spatial ordering.
  • Revealed universal strategies for rapid, robust, and efficient spatial organization in biological systems.