Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

pH Scale02:41

pH Scale

79.6K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
79.6K
Population Growth00:57

Population Growth

28.4K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.4K
What is Population Genetics?01:25

What is Population Genetics?

64.7K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.7K
Conservation of Small Populations02:04

Conservation of Small Populations

17.1K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.1K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.8K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.8K
What are Populations and Communities?00:30

What are Populations and Communities?

37.6K
Overview
37.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A dish-to-biobank framework links β-cell nutrient-stress programs to genetic and dietary risk for Type 2 Diabetes.

bioRxiv : the preprint server for biology·2026
Same author

<i>SPP1</i><sup>hi</sup> macrophages in fibrin niches promote hyperplastic tissue remodeling in rheumatoid arthritis synovium.

Science translational medicine·2026
Same author

Analysis of 173,303 exomes and genomes in the Pakistan Genome Resource.

Nature·2026
Same author

Non-Enzymatic MGO-Glycation of SRSF2 Drives RNA Mis-Splicing.

Journal of the American Chemical Society·2026
Same author

Resolving human neuronal herpesvirus reactivation via petabase-scale association studies.

bioRxiv : the preprint server for biology·2026
Same author

Scalable genotyping in fixed transcriptomes resolves clonal heterogeneity via single-cell sequencing.

bioRxiv : the preprint server for biology·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
Same journal

Towards the construction of a virtual yeast.

Nature·2026
Same journal

Aerosols and hydrocarbons in the atmosphere of a white dwarf planet.

Nature·2026
Same journal

TROP2 targeting reveals therapy-driven cell state dynamics in colorectal cancer.

Nature·2026
Same journal

Competing programs shape cortical sensorimotor-association axis development.

Nature·2026
Same journal

Steatosis shapes prognosis-defining liver metastasis heterogeneity in CRC.

Nature·2026
See all related articles

Related Experiment Video

Updated: Jan 30, 2026

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
12:29

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

2.7K

Population-scale sequencing resolves determinants of persistent EBV DNA.

Sherry S Nyeo1,2, Erin M Cumming1, Oliver S Burren3

  • 1Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature
|January 28, 2026
PubMed
Summary
This summary is machine-generated.

Persistent Epstein-Barr virus (EBV) DNA levels are linked to various diseases. Genetic factors, particularly in immune regulation and antigen processing, influence EBV persistence and disease risk.

More Related Videos

Culture and Assay of Large-Scale Mixed-Stage Caenorhabditis elegans Populations
08:51

Culture and Assay of Large-Scale Mixed-Stage Caenorhabditis elegans Populations

Published on: May 5, 2021

5.6K
Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
11:12

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

7.9K

Related Experiment Videos

Last Updated: Jan 30, 2026

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli
12:29

Population and Single-Cell Analysis of Antibiotic Persistence in Escherichia coli

Published on: March 24, 2023

2.7K
Culture and Assay of Large-Scale Mixed-Stage Caenorhabditis elegans Populations
08:51

Culture and Assay of Large-Scale Mixed-Stage Caenorhabditis elegans Populations

Published on: May 5, 2021

5.6K
Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach
11:12

Determination of the Optimal Chromosomal Locations for a DNA Element in Escherichia coli Using a Novel Transposon-mediated Approach

Published on: September 11, 2017

7.9K

Area of Science:

  • Genetics
  • Virology
  • Immunology
  • Bioinformatics

Background:

  • Epstein-Barr virus (EBV) is a widespread herpesvirus associated with autoimmune diseases, cancers, and neurological disorders.
  • Primary EBV infection is often asymptomatic, but persistent infection can lead to immune dysregulation and chronic health issues.
  • The genetic factors determining EBV persistence after initial exposure are not well understood.

Purpose of the Study:

  • To investigate the genetic architecture of persistent Epstein-Barr virus DNA.
  • To identify host genetic factors influencing EBV DNA levels using large-scale population data.
  • To explore the association between EBV DNA load and various non-cancerous diseases.

Main Methods:

  • Utilized whole genome sequencing (WGS) and health record data from UK Biobank (n=490,560) and All of Us (n=245,394) cohorts.
  • Quantified persistent EBV DNA in blood samples using WGS data.
  • Conducted genome-wide association studies (GWAS) to identify genetic determinants and analyzed gene expression and HLA data.

Main Results:

  • Established a reproducible method to quantify EBV DNA from existing WGS data.
  • Identified significant associations between EBV DNA levels and respiratory, autoimmune, neurological, and cardiovascular diseases.
  • Discovered genetic heritability for EBV DNA persistence enriched in immune regulatory regions and identified 148 candidate genes, implicating variable antigen processing and HLA class II variation.

Conclusions:

  • Re-analysis of population-scale WGS data can effectively elucidate the genetic basis of viral DNA persistence.
  • Host genetic variation significantly modulates EBV DNA persistence, influencing susceptibility to a spectrum of diseases.
  • This framework is generalizable for studying the genetic underpinnings of other viral infections within the human virome.