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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Review and Preview01:10

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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
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Review and Preview01:13

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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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Mechanisms of Retrovirus-induced Cancers01:51

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Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Cancer Therapy-Induced Cardiotoxicity: A Narrative Review.

Drew A Wells1, Zachery Halford2, Kori Holman3

  • 1Department of Pharmacy, Internal Medicine, Methodist Le Bonheur Healthcare - University Hospital, Memphis, Tennessee, USA.

Pharmacotherapy
|January 28, 2026
PubMed
Summary

Cancer therapy-induced cardiotoxicity (CTIC) presents a growing challenge. Broader clinical awareness of CTIC mechanisms and cardiovascular strategies is crucial for preventing long-term harm in cancer patients.

Keywords:
HER2 inhibitorsanthracyclinecardiotoxicitychemotherapy‐induced cardiotoxicity

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Area of Science:

  • Cardio-oncology
  • Oncology
  • Cardiovascular Medicine

Background:

  • Cancer therapy-induced cardiotoxicity (CTIC) is a significant clinical challenge.
  • Evolving oncologic treatments introduce diverse cardiovascular risks beyond traditional chemotherapy.

Purpose of the Study:

  • To synthesize evidence on CTIC definitions, mechanisms, agents, and prevention.
  • To highlight the need for broader clinical familiarity with CTIC and cardiovascular optimization.

Main Methods:

  • Comprehensive narrative review of clinical trials, meta-analyses, and guidelines.
  • Examination of various therapeutic agents and their cardiovascular event risks.

Main Results:

  • Numerous agents beyond chemotherapy cause arrhythmias, hypertension, myocardial dysfunction, and vascular complications.
  • Individualized monitoring strategies are necessitated by varied toxicity profiles.

Conclusions:

  • Non-oncology practitioners increasingly encounter CTIC, requiring enhanced familiarity.
  • Further cardio-oncology trials and multidisciplinary collaboration are needed for optimal CTIC prevention and treatment.