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Functional Training Mitigates Reduced Circulating Indole-3-Lactate Levels in Persons With Relapsing-Remitting

Tiffany Wences Chirino1, Frederike Adammek1, Sergen Belen1,2

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Summary
This summary is machine-generated.

Regular exercise and a 10-week multimodal training program significantly improved the indole-3-lactate/indole-3-acetate index in multiple sclerosis patients. A single exercise session also boosted indole-3-lactate levels, suggesting neuroprotective benefits.

Keywords:
exercisegut microbiotaindolesmultiple sclerosistryptophan

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Area of Science:

  • Neuroscience
  • Microbiology
  • Immunology

Background:

  • Indoles, tryptophan-derived gut microbial metabolites, influence the gut-brain axis in multiple sclerosis (MS).
  • Indole-3-lactate (ILA) is reduced in MS patients and shows anti-inflammatory, remyelinating properties in animal models.
  • The ILA/indole-3-acetate (IAA) ratio (ILA/IAA) serves as a neuroprotection index, modifiable by exercise and diet.

Purpose of the Study:

  • To investigate the effects of acute and chronic exercise on serum indole levels in relapsing-remitting MS (RRMS) patients.
  • To assess the impact of a 10-week multimodal functional training program on the ILA/IAA index.
  • To evaluate the acute effects of a single exercise bout on circulating indole levels.

Main Methods:

  • Secondary analysis of a randomized controlled trial involving 31 RRMS patients.
  • Comparison of serum indole concentrations (measured by LC-MS/MS) at baseline, post-10-week intervention, and in matched healthy controls.
  • Assessment of acute exercise effects via blood sampling before, during, and immediately after a training session.

Main Results:

  • RRMS patients exhibited different baseline indole levels compared to healthy controls, with reduced ILA.
  • Chronic multimodal training (10 weeks) significantly increased the ILA/IAA index.
  • An acute bout of exercise led to increased levels of both ILA and the ILA/IAA index.

Conclusions:

  • A 10-week multimodal functional training program improved the ILA/IAA index in RRMS patients, indicating a potential neuroprotective shift in gut microbiota.
  • Acute exercise can rapidly increase circulating ILA levels.
  • Exercise interventions show promise for modulating gut microbiota metabolites and supporting neuroprotection in MS.