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Association between adverse childhood experiences and asthma: a protocol for meta-analysis
Liqiong Wang1, Yungai Cheng2, Yuqi Wang3,4
1Department of Mental Health Center, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, People's Republic of China.
Systematic Reviews
|January 29, 2026
Summary
Adverse childhood experiences (ACEs) are linked to asthma development, though controversial. This systematic review and meta-analysis will clarify the association between various ACEs and asthma, aiming to improve child well-being.
Area of Science:
- Pediatric Health
- Environmental Epidemiology
- Public Health
Background:
- Adverse Childhood Experiences (ACEs) are increasingly recognized as significant risk factors for chronic health conditions.
- The association between ACEs and asthma development is debated, necessitating rigorous investigation.
- PROSPERO registration: CRD42024544950.
Purpose of the Study:
- To systematically review and meta-analyze the existing evidence on the association between diverse ACEs and asthma.
- To provide a comprehensive evaluation of the ACEs-asthma link, addressing current controversies.
- To inform strategies for mitigating asthma risk in children exposed to ACEs.
Main Methods:
- A systematic literature search will be conducted across major databases (PubMed, Embase, Cochrane, Web of Science) up to April 30, 2025.
- Data extraction will include study characteristics, population demographics, and specific ACEs-asthma associations.
- Study quality will be assessed using the Newcastle-Ottawa Scale (NOS); meta-analysis or descriptive synthesis will be employed.
Main Results:
- This section will present the synthesized findings from the included studies regarding the association between various ACEs and asthma.
- Quantitative meta-analysis will be performed where feasible to determine the strength and direction of the relationship.
- Results will be presented clearly, addressing heterogeneity and potential biases.
Conclusions:
- This systematic review and meta-analysis will elucidate the relationship between different ACEs and asthma.
- Findings aim to support interventions reducing asthma incidence and improving quality of life for children with ACEs.
- The study contributes robust evidence to the fields of child development and respiratory health.
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