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Related Experiment Video

Updated: Jan 30, 2026

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

Catalytic Amyloids: Turning Fibrils Into Biocatalysts.

Alessandra Esposito¹, Linda Leone¹, Flavia Nastri¹

¹Department of Chemical Sciences, University of Napoli Federico II, Napoli, Italy.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|January 29, 2026

Summary

Catalytic amyloids merge enzyme efficiency with robust nanomaterial properties. This review explores their development and application as stable scaffolds for catalysis and enzyme immobilization, creating innovative biomaterials.

Keywords:

amyloids biocatalysis metalloenzymes nanomaterials peptides

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Area of Science:

Biomaterials Science
Nanotechnology
Catalysis

Background:

Amyloids were historically linked to neurodegenerative diseases.
Recent discoveries highlight their physiological roles and self-assembly into stable scaffolds.
This opens avenues for novel applications in materials science and nanotechnology.

Purpose of the Study:

To review the structural and functional properties of natural amyloids and their nanotechnology applications.
To survey the development of catalytic amyloids, including bioinspired and de novo designs.
To illustrate the use of amyloid fibrils for enzyme immobilization.

Main Methods:

Overview of natural amyloid properties and applications.
Survey of catalytic amyloid development strategies.
Examples of amyloid fibrils as platforms for enzyme immobilization.

Main Results:

Amyloids possess unique self-assembly properties suitable for nanomaterial development.
Incorporation of functional groups imparts catalytic activity to amyloid fibrils.
Amyloid fibrils serve as effective platforms for enzyme immobilization, enhancing catalytic efficiency.

Conclusions:

Catalytic amyloids represent a new class of nanomaterials combining enzymatic efficiency with heterogeneous catalyst robustness.
Bridging amyloid structures and catalytic activities enables the creation of innovative nanomaterials for diverse applications.
Amyloid-based nanomaterials offer a promising platform for advanced catalysis and biocatalysis.