Effect of Noni Fruit Extract Microcapsules on the Profile and Biochemistry of Sentul Chicken Blood in the Layer Phase

<b>Background and Objective:</b> Noni fruit (<i>Morinda citrifolia</i> L.) contains bioactive compounds with the potential to improve lipid metabolism, reduce inflammation and enhance poultry health. However, its application in poultry feed remains underexplored. This study aimed to evaluate the effect of noni fruit extract microcapsules (NFEM) on lipid profile, blood biochemistry and inflammatory markers in Sentul chickens during the laying phase. <b>Materials and Methods:</b> A total of 40 hens aged 24 weeks were randomly allocated into five dietary treatments: Control (T1), 50 mg/kg zinc bacitracin (T2), 75 mg/kg NFEM (T3), 150 mg/kg NFEM (T4) and 225 mg/kg NFEM (T5). Blood samples were analyzed for lipid profile, liver function markers and hematological parameters. Data were subjected to Analysis of Variance (ANOVA) and differences among treatments were tested using Duncan's Multiple Range test at a significance level of p<0.05. <b>Results:</b> Dietary supplementation with NFEM significantly decreased LDL cholesterol levels and increased HDL cholesterol levels (p<0.05). A notable reduction in leukocyte and lymphocyte counts indicated lowered inflammation in NFEM-treated groups. Blood biochemical parameters further suggested improved liver function compared with the control. <b>Conclusion:</b> Noni fruit extract microcapsules improved lipid metabolism, reduced inflammation and supported liver function in Sentul chickens during the laying phase. These findings highlight the potential of NFEM as a natural feed additive to enhance poultry health and productivity.