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Updated: Jan 30, 2026

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
Published on: January 17, 2020
An Iridium-Catalyzed Conia-ene Reaction for the Diastereo- and Enantioselective Synthesis of Complex Ring Systems
Romi S Aggarwal1, Wenbin Mao1, Craig M Robertson1
1Department of Chemistry, University of Liverpool, Crown Street, Liverpool, L69 7ZD, UK.
Abstract:
Iridium-catalyzed Conia-ene reactions of α-amino amides are described. These units undergo 6- or 7-exo cyclization onto amido-tethered alkenes to provide benzofused N-heterocycles. In this process, challenging contiguous stereocenters are installed with high diastereo- and enantioselectivity. The method provides a versatile platform for constructing sp3-rich heterocycles, and offers unusual examples of alkenes engaging in enantio- and diastereoselective Conia-ene reactions. This study adds to an emerging body of processes that exploit the directed generation of Ir-enolates.
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