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Published on: September 6, 2024
Immature platelet fraction as a prognostic marker in patients with pulmonary embolism
Akiva Brin1, Ranel Loutati2, Ariella Tvito3
1Jesselson Heart Center, Shaare Zedek Medical Center, the Eisenberg R&D Authority, and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
Insights
Elevated immature platelet fraction (IPF) indicates higher mortality risk in acute pulmonary embolism (PE) patients. This finding suggests IPF can predict short-term outcomes in PE.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Pulmonary Medicine
Background:
- Immature platelet fraction (IPF) is linked to adverse outcomes in cardiovascular diseases.
- Limited data exists on IPF's prognostic role in acute pulmonary embolism (PE).
- Understanding IPF's significance in PE is crucial for risk stratification.
Purpose of the Study:
- To investigate the prognostic value of IPF levels in patients diagnosed with acute PE.
- To determine the association between IPF and mortality outcomes in acute PE.
Main Methods:
- A cohort of 166 patients with confirmed acute PE admitted to an intensive cardiovascular care unit (ICCU) was studied.
- IPF levels were measured using an autoanalyzer (Sysmex XN-2000).
- Correlation between IPF levels and all-cause mortality at 30 days and one year was assessed using multivariate logistic regression.
Main Results:
- The study included 166 patients (55.4% male, mean age 65.0 years).
- Overall one-year mortality was 9.0% (15 patients), and 30-day mortality was 4.8% (8 patients).
- Elevated IPF levels were independently associated with increased 30-day mortality (OR 1.36) and one-year mortality (OR 1.23).
Conclusions:
- Higher IPF levels are independently linked to increased 30-day and one-year mortality in acute PE patients.
- IPF shows potential as a prognostic biomarker for short-term outcomes in acute pulmonary embolism.
- Further research may validate IPF for routine clinical use in PE risk assessment.
Introduction:
Immature platelet fraction (IPF), a population of young platelets with distinct histological and functional characteristics, is associated with adverse outcomes in several cardiovascular diseases. However, data on the role of IPF in acute pulmonary embolism (PE) is limited. The objective of this study was to evaluate the prognostic significance of IPF levels in patients with acute PE.
Methods:
All patients admitted to a tertiary care center's intensive cardiovascular care unit (ICCU) with confirmed diagnosis of acute PE from July 2019 to July 2024 were included. IPF measurement was carried out using an autoanalyzer (Sysmex XN-2000). The correlation between IPF level and outcome of all-cause mortality was assessed.
Results:
A total of 166 patients were included. Mean age of 65.0 years (±17.3), of whom 92 (55.4%) were male. The overall one-year mortality rate was 9.0% (15 patients), while the 30-day mortality rate was 4.8% (8 patients). Multivariate logistic regression analysis demonstrated that elevated IPF levels were independently associated with increased 30-day mortality (OR 1.36; 95% CI 1.06-1.80, p = .017) and one-year mortality (OR 1.23; 95% CI 1.02-1.5, p = .03).
Conclusions:
Elevated IPF levels are independently associated with increased 30-day and one-year mortality in patients with acute PE. These findings highlight the potential of IPF as a prognostic marker for short-term outcomes in this patient population.
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