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Separation and detection of ginsenosides: Challenges, industrial implications, and developments
Anqi Liu1, Junjun Zhou2, Yiling Luo3
1College of Biological Engineering, Henan University of Technology, Zhengzhou 450001, Henan Province, China; Henan Provincial Engineering Laboratory of Preservation and Breeding of Industrial Microbial Strains, Zhengzhou 450001, China.
Food Research International (Ottawa, Ont.)
|January 29, 2026
Summary
Ginsenoside extraction and detection face challenges. Advanced methods like molecularly imprinted polymers and spectroscopy offer improved efficiency and scalability for functional foods.
Area of Science:
- Pharmacology and Food Science
- Natural Product Chemistry
Background:
- Ginsenosides from Panax ginseng are valued for anticancer properties.
- Growing demand for ginsenoside-enriched foods highlights challenges in current separation and detection.
Purpose of the Study:
- To review recent advances in ginsenoside separation and detection technologies.
- To evaluate their potential for efficient, selective, and scalable production.
Main Methods:
- Analysis of traditional methods (MAR, LLS, HPLC) and their limitations.
- Exploration of advanced strategies: molecularly imprinted polymers, biotransformation, green solvents.
- Assessment of non-destructive analytical platforms (NIR, HSI, Raman spectroscopy) for quality control.
Main Results:
- Traditional methods show low yields, complex purification, and limited real-time monitoring.
- Advanced techniques offer enhanced efficiency, selectivity, and sustainability.
- Non-destructive platforms enable rapid, online quality control.
Conclusions:
- Overcoming current limitations requires adopting advanced separation and detection technologies.
- Future research should focus on optimizing these methods for large-scale, sustainable ginsenoside production.
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