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Bidirectional nexus between metabolic disease and aortic valve calcification: from pathogenic mechanisms to

Xinyue Wang1,2, Mincheng Yu1,2, Jingzheng Chen1,2

  • 1Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, China.

Expert Opinion on Therapeutic Targets
|January 29, 2026
PubMed

Insights

Calcified aortic valve disease (CAVD) lacks effective drug treatments. This review explores the link between metabolic diseases and aortic valve calcification (AVC), proposing a "calcification-metabolic axis" for new therapeutic targets.

Area of Science:

  • Cardiology
  • Metabolic Diseases
  • Pathophysiology

Background:

  • Calcified aortic valve disease (CAVD) presents a significant global health challenge.
  • Current treatment for CAVD primarily relies on valve replacement surgery.
  • There is an urgent need for effective pharmacotherapy to manage CAVD.

Purpose of the Study:

  • To systematically review the epidemiological links between metabolic diseases and aortic valve calcification (AVC).
  • To elucidate common mechanistic pathways connecting metabolic disorders and AVC.
  • To introduce the 'calcification-metabolic axis' as a framework for understanding CAVD.

Main Methods:

  • Comprehensive literature search of the PubMed database up to December 2025.
  • Focus on studies investigating CAVD, metabolism, inflammation, and calcification signaling.
  • Systematic evaluation of epidemiological associations and mechanistic pathways.

Main Results:

  • Metabolic diseases are epidemiologically associated with aortic valve calcification (AVC).
  • Common mechanistic pathways, termed the 'calcification-metabolic axis', link metabolic dysfunction to AVC.
  • Inflammation and specific calcification signaling pathways are implicated.

Conclusions:

  • Future CAVD management should integrate early, multi-disease co-governance.
  • Development of targeted drugs for pathways within the 'calcification-metabolic axis' is crucial.
  • Pharmacotherapy holds promise to advance beyond current reliance on surgical valve replacement.
Abstract

Keywords:
Aortic valve calcificationepidemiologymetabolic diseasesmultimorbiditypathological mechanisms

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