Brief report: Ketamine-assisted "bridge therapy" for opioid tapering in complex cases
Mariana C de Oliveira1,2, Cláudia C de Araujo Palmeira1,2, André B Negrão1,2
1Instituto Perdizes (IPER), Department of Psychiatry, Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, 05021-001, São Paulo, Brazil.
Background:
Opioid use disorder (OUD) presents major challenges, especially when combined with chronic pain and psychiatric comorbidities. A 25-year-old woman with OUD, chronic pain, and major depressive disorder underwent an 8-week protocol of intravenous ketamine infusions (0.5 mg/kg weekly) as an adjunct to opioid tapering.
Results:
Methadone dosage was reduced by 50%, with improved pain and craving control, reduced withdrawal symptoms, and greater psychotherapy engagement.
Discussion And Conclusions:
Ketamine-assisted "bridge therapy" treatment may support opioid tapering in complex cases.
Scientific Significance:
This is a novel report to document a multifaceted improvement in this specific comorbidity cluster.
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