Multicomponent Reaction Strategies for the Synthesis of 4-(Indol-3-Yl)-4H-Chromene Derivatives: Recent Developments
Elizabeth J Diana1,2, Jisna Jose1, Thomas V Mathew1
1Department of Chemistry, St Thomas College Palai, Arunapuram P.O., Kottayam, Kerala, 686574, India.
Abstract:
This review highlights recent advancements (2021-2025) in the synthesis of 4-(indol-3-yl)-4H-chromene derivatives, a promising class of compounds with diverse biological activities, including anticancer, antifungal, antitumor, anti-HIV, and antioxidant properties. The focus is on multicomponent reactions (MCRs) as a valuable tool for efficient synthesis, offering benefits such as environmental sustainability and precise targeting. The review explores MCR strategies and substrate scope, shedding light on their potential therapeutic applications.
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