Noncoding RNAs in Obesity and Related Disorders

Area of Science:

• Genomics
• Molecular Biology
• Metabolic Diseases

Background:

• Obesity is a global health crisis linked to metabolic disorders like type 2 diabetes and cardiovascular disease.
• While genetics and environment contribute, noncoding RNAs (ncRNAs) are emerging as critical regulators in obesity.
• Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) influence key obesity pathways such as adipogenesis and insulin resistance.

Purpose of the Study:

• To review the current evidence on the roles of lncRNAs and circRNAs in obesity and its complications.
• To highlight the potential of ncRNAs as biomarkers for obesity-related conditions.
• To discuss ncRNAs as therapeutic targets for advancing precision medicine in obesity treatment.

Main Methods:

• Systematic review of transcriptomic studies and relevant literature.
• Synthesis of evidence on ncRNA regulation in adipogenesis, inflammation, insulin resistance, and energy homeostasis.
• Analysis of current challenges and future strategies for clinical translation of ncRNA research.

Main Results:

• lncRNAs and circRNAs play significant regulatory roles in multiple facets of obesity.
• These ncRNAs demonstrate potential as diagnostic and prognostic biomarkers.
• ncRNAs offer promising avenues for novel therapeutic interventions.

Conclusions:

• ncRNAs are crucial players in obesity pathogenesis and its associated metabolic disorders.
• Further research into ncRNA biology is essential for developing effective biomarkers and therapies.
• Integrative strategies are needed to translate ncRNA findings into clinical practice for precision obesity medicine.