Related Experiment Video
Updated: Jan 30, 2026
05:53
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
10.7K
Association Between Psoriasis Risk and Body Mass Index and Waist Circumference in Diabetes: A Population-Based Cohort
Seungah Yoo1, Kyungdo Han2, Ji Hyun Lee3
1Department of Dermatology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Annals of Dermatology
|January 29, 2026
Summary
Obesity, measured by BMI and waist circumference, is linked to increased psoriasis risk in type 2 diabetes patients. This finding may improve diabetes management strategies.
Area of Science:
- Endocrinology
- Dermatology
- Epidemiology
Background:
- Psoriasis is associated with diabetes and obesity.
- Limited understanding of obesity's impact on psoriasis risk in diabetic individuals.
Purpose of the Study:
- Examine the association between body mass index (BMI) and waist circumference (WC) with psoriasis risk in type 2 diabetes mellitus (T2DM) patients.
Main Methods:
- Retrospective nationwide cohort study.
- Included 2,480,489 participants diagnosed with T2DM.
- Follow-up period of 6.77±1.69 years.
Main Results:
- 71,514 patients (2.88%) developed psoriasis.
- J-shaped association between BMI and psoriasis risk.
- Linear association between WC and psoriasis risk, with highest WC showing elevated hazard ratio (HR=1.123).
Conclusions:
- Obesity is a significant factor in psoriasis development among T2DM patients.
- Understanding this relationship can enhance T2DM patient management.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
15.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.6K
01:12Reduced Mass Coordinates: Isolated Two-body Problem
2.4K
In classical mechanics, the two-body problem is one of the fundamental problems describing the motion of two interacting bodies under gravity or any other central force. When considering the motion of two bodies, one of the most important concepts is the reduced mass coordinates, a quantity that allows the two-body problem to be solved like a single-body problem. In these circumstances, it is assumed that a single body with reduced mass revolves around another body fixed in a position with an...
2.4K
02:04Conservation of Small Populations
17.1K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
17.1K
01:25What is Population Genetics?
64.7K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.7K
00:30What are Populations and Communities?
37.6K
Overview
37.6K
00:57Population Growth
28.4K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
28.4K