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Updated: Jan 30, 2026

Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks
Published on: December 21, 2019
NIR-Triggered 3D-Bioprinted Hydrogels for Antibacterial Skin Regeneration
Hongyu Wen1,2, Qian Chen3, Peng Zhang1,2
1Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China.
Abstract:
Near-infrared (NIR)-triggered hydrogen-bonding condensation utilizing up-conversion nanoparticles (UCNPs)-incorporated poly of acrylic acid-N-vinyl-2-pyrrolidone (AA-NVP) and carboxymethyl cellulose (CMC) as AA-NVP/CMC hydrogels was explored, where the photoconversion of the corresponding fluoride UCNPs endows NIR-mediated hydrogels fabrication for the efficient optical output. Accordingly, the developed hydrogels as bio-ink realize a 3D-printing in vivo. Moreover, the printed hydrogels generate reactive oxygen species (ROS) to provide potent bactericidal effects for photodynamic therapy (PDT), in conjunction with photothermal effects (PTE). It circumvents the antibiotic resistance issues associated with conventional antimicrobial agents, which fundamentally promotes skin regeneration from the inner layers of the skin to the outer layers with the synergistic antibacterial therapy.
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