Alpha-Synuclein Dynamics in Cerebral Ischemia.

Area of Science:

• Neuroscience
• Pathophysiology
• Biochemistry

Background:

• Cerebral ischemia, characterized by insufficient brain blood supply, is a major global cause of death and disability.
• Alpha-synuclein (α-Syn) is implicated in neurodegenerative diseases and cerebral ischemia pathophysiology.

Purpose of the Study:

• To provide a comprehensive review of alpha-synuclein's role in cerebral ischemia.
• To explore potential therapeutic strategies targeting alpha-synuclein for ischemic brain injury.

Main Methods:

• Narrative review of existing literature on alpha-synuclein and cerebral ischemia.
• Analysis of alpha-synuclein's impact on neuroinflammation, synaptic function, oxidative stress, and cell death.
• Examination of therapeutic approaches, biomarker potential, and expression changes.

Main Results:

• Alpha-synuclein influences key mechanisms of ischemic brain injury, including neuroinflammation and neuronal death.
• Alpha-synuclein exhibits both detrimental and potentially protective roles in cerebral ischemia.
• Changes in alpha-synuclein expression are observed in animal and human studies.

Conclusions:

• Clarifying the complex role of alpha-synuclein in cerebral ischemia is crucial for understanding ischemic brain injury.
• Targeting alpha-synuclein presents promising therapeutic avenues for treating cerebral ischemia.
• Alpha-synuclein may serve as a potential diagnostic biomarker for cerebral ischemia.