Revolutionizing dental restorations: Insights into computer-aided design/computer-aided manufacturing materials - A...

The integration of computer-aided design (CAD) and computer-aided manufacturing (CAM) technology has significantly transformed restorative dentistry. This review explores the game-changing influence of CAD/CAM systems in restorative dentistry, emphasizing the clinical performance, mechanical attributes, and esthetic potential of contemporary materials such as zirconia, lithium disilicate, polyetheretherketone, polymethylmethacrylate, and advanced resin composites.This systematic review, conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and structured using the PICO framework, comprehensively explored evidence on CAD/CAM dental materials. A thorough search of PubMed, Scopus, Cochrane Library, Web of Science, and Google Scholar (2015-2025) initially identified 1300 records. After rigorous screening and eligibility assessment, studies addressing clinical indications, mechanical performance, and material-specific outcomes of CAD/CAM restorations were included for qualitative synthesis. Lithium disilicate and zirconia emerged as frontrunners in fracture resistance, marginal adaptation, and long-term esthetics. Glass-ceramics and nanohybrid composites demonstrated high performance in posterior and veneer applications. Comparative trials favored CAD/CAM over conventional restorations in precision, fit, and durability. Risk-of-bias assessment indicated predominantly low bias across key domains, ensuring reliability of findings. CAD/CAM materials combine digital precision with clinical excellence, offering strong mechanical performance and refined esthetics for optimal functional outcomes. Clinical evidence highlights their accuracy, efficiency, and long-term success compared to traditional restorative techniques.