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Updated: Jan 30, 2026

Non-invasive Optical Measurement of Cerebral Metabolism and Hemodynamics in Infants
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CD71+ erythroid cells as a potential early biomarker for hemodynamic significant patent ductus arteriosus in preterm

Ju Ae Shin1, Jae Young Lee1, Jeongmin Shin1

  • 1Department of Pediatrics, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Frontiers in Immunology
|January 29, 2026
PubMed

Insights

Elevated CD71+ erythroid cells (CECs) in preterm infants can predict the risk of hemodynamically significant patent ductus arteriosus (hsPDA). Early CEC measurement may improve early detection and intervention for hsPDA in neonates.

Area of Science:

  • Neonatal Medicine
  • Pediatric Cardiology
  • Hematology

Background:

  • Hemodynamically significant patent ductus arteriosus (hsPDA) in preterm infants is linked to poor outcomes.
  • Early identification of infants at risk for hsPDA is crucial for timely intervention.
  • Perinatal inflammation is a known risk factor for PDA, and CD71+ erythroid cells (CECs) possess immunomodulatory properties.

Purpose of the Study:

  • To investigate the association between CEC levels and the development of hsPDA in preterm infants.
  • To determine if CECs can serve as an early predictive biomarker for hsPDA.

Main Methods:

  • A prospective study involving 108 preterm infants (born before 37 weeks gestation).
  • Quantification of CEC levels using flow cytometry within 12 hours of birth.
  • Assessment of hsPDA via echocardiography between days 3 and 7 post-birth.

Main Results:

  • CEC levels showed a significant inverse correlation with gestational age and hematologic parameters (hemoglobin, RBC, WBC, platelets).
  • Infants who developed hsPDA had significantly higher CEC levels compared to those without hsPDA.
  • Elevated CEC levels and lower white blood cell count were identified as independent predictors of hsPDA.

Conclusions:

  • Early measurement of CEC levels can identify preterm infants at high risk for hsPDA.
  • CECs show potential as a predictive biomarker for hsPDA, aiding in risk stratification and timely intervention.
  • Further research is warranted to understand the underlying mechanisms connecting CECs and hsPDA.
Abstract

Keywords:
CD71+ erythroid cellhemodynamically significant patent ductus arteriosusimmunoregulationpatent ductus arteriosuspreterm infants

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