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Intergenerational Associations of Hypertensive Disorders of Pregnancy With Offspring Metabolomics: A Systematic

Jinrui Xiong1,2, Ling-Jun Li3,4,5,6, Yongping Zhang1,2

  • 1School of Public Health, Jiangxi Medical College, Nanchang University, Jiangxi, Nanchang 330006, China.

Maternal-Fetal Medicine (Wolters Kluwer Health, Inc.)
|January 29, 2026
PubMed

Insights

Hypertensive disorders of pregnancy (HDP) alter offspring blood metabolomics, particularly lipids and amino acids. This suggests an intergenerational effect requiring further investigation into long-term health outcomes.

Area of Science:

  • Perinatal medicine
  • Metabolomics
  • Genetics and epigenetics

Background:

  • Hypertensive disorders of pregnancy (HDP) encompass conditions like preeclampsia and gestational hypertension.
  • These disorders can have lasting impacts on maternal and fetal health.
  • Understanding offspring metabolomics provides insights into developmental programming.

Purpose of the Study:

  • To synthesize current evidence on the impact of HDP on offspring metabolomics.
  • To identify specific metabolic alterations in neonates exposed to HDP in utero.
  • To explore the potential for intergenerational effects of HDP.

Main Methods:

  • Systematic literature search across five major databases (PubMed, Embase, MEDLINE, Web of Science, CNKI).
  • Inclusion of observational studies reporting metabolomics data in offspring of mothers with HDP.
  • Full-text screening of 4054 retrieved articles to identify ten eligible studies.

Main Results:

  • Offspring exposed to HDP exhibited significant variations in blood metabolomics, including amino acids, lipids, and carnitine.
  • Most studies reported increased concentrations of differential metabolites in HDP-exposed offspring.
  • Four studies consistently showed significantly higher lipid concentrations in offspring born to pregnancies with preeclampsia.

Conclusions:

  • Evidence suggests an intergenerational influence of HDP on offspring metabolic profiles.
  • Further long-term follow-up studies are crucial to assess adverse health outcomes.
  • Findings can inform preventative strategies for offspring health impacted by maternal HDP.
Abstract

Keywords:
Gestational hypertensionHyptertensive disorders of pregnancyIntergenerational associationsMetabolomicsPreeclampsia

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