Related Experiment Video

Updated: Jan 30, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
07:30

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions

Published on: April 23, 2021

3.4K

Cerebrovascular Complications in Bacterial Meningitis

Shahrzad S Deliran1,2, Matthijs C Brouwer1, Diederik van de Beek1

  • 1Department of Neurology, Amsterdam Neuroscience Amsterdam UMC, University of Amsterdam Amsterdam The Netherlands.

Stroke (Hoboken, N.J.)
|January 29, 2026
PubMed

Insights

Bacterial meningitis frequently leads to cerebrovascular complications like stroke and hemorrhage, significantly increasing mortality risk. Early identification and novel treatments are crucial for improving patient outcomes.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Vascular Medicine

Background:

  • Bacterial meningitis can lead to severe neurological deficits.
  • Cerebrovascular complications are a significant concern in meningitis patients.

Purpose of the Study:

  • To analyze the occurrence and types of cerebrovascular complications in adult bacterial meningitis patients.
  • To review the associated pathogens and pathophysiological mechanisms.
  • To highlight the impact of these complications on patient outcomes.

Main Methods:

  • Literature review of adult patients with bacterial meningitis and cerebrovascular complications.
  • Analysis of reported incidence rates for various cerebrovascular events.
  • Identification of common causative pathogens and proposed pathophysiological pathways.

Main Results:

  • Cerebrovascular complications affect approximately 25% of bacterial meningitis patients.
  • Common complications include cerebral infarctions (9%-25%), cerebral venous thrombosis (1%-10%), intracerebral hemorrhage (1%-7%), and subarachnoid hemorrhage (1%-5%).
  • Streptococcus pneumoniae and Staphylococcus aureus are primary pathogens; mechanisms involve vasculitis, endothelial dysfunction, and hypercoagulability.

Conclusions:

  • Cerebrovascular complications are frequent in bacterial meningitis and predict poor outcomes and mortality.
  • Adjunctive dexamethasone may reduce complication incidence.
  • Further research into novel therapeutic strategies is needed to manage these complications effectively.

Keywords:
bacterial meningitiscerebral venous thrombosiscerebrovascular complicationdelayed cerebral thrombosisintracerebral hemorrhagestreptococcus pneumoniastrokesubarachnoid hemorrhage

More Related Videos

Imaging and 3D Reconstruction of Cerebrovascular Structures in Embryonic Zebrafish08:00

Imaging and 3D Reconstruction of Cerebrovascular Structures in Embryonic Zebrafish

Published on: April 22, 2014

15.3K
Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells09:35

Isolating Central Nervous System Tissues and Associated Meninges for the Downstream Analysis of Immune cells

Published on: May 19, 2020

10.9K

Related Concept Videos

Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
4.0K
Hemodialysis II: Procedure and Complications01:24

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...
790
Pneumonia III: Complications and Assessment01:30

Pneumonia III: Complications and Assessment

Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
851
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.3K
Bacterial Transformation01:33

Bacterial Transformation

In 1928, bacteriologist Frederick Griffith worked on a vaccine for pneumonia, which is caused by Streptococcus pneumoniae bacteria. Griffith studied two pneumonia strains in mice: one pathogenic and one non-pathogenic. Only the pathogenic strain killed host mice.
Griffith made an unexpected discovery when he killed the pathogenic strain and mixed its remains with the live, non-pathogenic strain. Not only did the mixture kill host mice, but it also contained living pathogenic bacteria that...
59.8K