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Related Experiment Video

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Measuring Left Ventricular Pressure in Late Embryonic and Neonatal Mice

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Left Ventricular Late Gadolinium Enhancement for Arrhythmic Risk Prediction in ARVC.

Corrado De Marco¹, Babken Asatryan², Anneline S J M Te Riele^3,4

¹Cardiovascular Genetics Center and Electrophysiology Service, Montreal Heart Institute, Department of Medicine, Université de Montréal, QC, Canada (C.D.M., R.T., L.-P.D., J.C.-T.).

Circulation. Arrhythmia and Electrophysiology

|January 29, 2026

Summary

This summary is machine-generated.

Left ventricular late gadolinium enhancement (LV LGE) on cardiac magnetic resonance is associated with ventricular arrhythmia (VA) risk in arrhythmogenic right ventricular cardiomyopathy (ARVC). However, LV LGE does not improve risk prediction beyond the existing ARVC risk calculator.

Keywords:

arrhythmias, cardiac death, sudden, cardiac heart ventricles prognosis risk assessment

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Area of Science:

Cardiology
Medical Imaging
Genetics

Background:

Arrhythmogenic right ventricular cardiomyopathy (ARVC) poses a risk for sustained ventricular arrhythmia (VA).
Current ARVC risk calculators do not incorporate left ventricular (LV) structure or function.
Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) shows potential for predicting arrhythmic events.

Purpose of the Study:

To determine if LV LGE on CMR can enhance risk stratification for VA in ARVC patients.
To assess the incremental prognostic value of LV LGE compared to the established ARVC risk calculator.

Main Methods:

A cohort of 385 ARVC patients without prior VA underwent baseline CMR.
Survival analysis and Cox proportional hazard models were used to evaluate LV LGE's impact on VA prediction.
High-risk LV LGE patterns (epicardial, transmural, combined septal/free-wall) were analyzed.

Main Results:

132 patients (34.3%) had LV LGE, with 98 (25.5%) exhibiting a high-risk pattern.
During follow-up (3.1 years), 67 patients (17.4%) experienced VA.
While LV LGE was associated with VA risk in univariable analysis, it did not independently predict VA after adjusting for the ARVC risk calculator score.

Conclusions:

LV LGE is associated with VA risk in ARVC patients.
LV LGE does not offer additional prognostic information for predicting incident VA when used with the current ARVC risk calculator.