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Behavioral Risk Factors and Seroprevalence for Human Papillomavirus in Sinonasal Carcinoma: A Multi-Institutional
Ved Tanavde1, Anuj Tharakan1, Gypsyamber D'Souza2
1Department of Otolaryngology Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Human papillomavirus-associated sinonasal carcinoma (HPV-SNC) shows unique serologic markers but lacks clear behavioral risk factors. Tonsillectomy may protect against HPV-SNC, suggesting a role for lymphoid tissue in its development.
Area of Science:
- Oncology
- Virology
- Epidemiology
Background:
- Sinonasal carcinomas are rare, aggressive cancers.
- A subset is linked to high-risk human papillomavirus (HPV).
- Risk factors for HPV-associated sinonasal carcinoma (HPV-SNC) and HPV-independent disease are poorly understood.
Purpose of the Study:
- To investigate behavioral and clinical risk factors for HPV-SNC and HPV-independent sinonasal carcinoma.
- To assess HPV antibody seropositivity in patients with these conditions.
Main Methods:
- A multi-institutional case-case-control study involving 52 sinonasal carcinoma patients and 148 controls.
- Electronic surveys collected data on demographics, behaviors, and medical history.
- Serum testing identified antibodies to HPV oncoproteins.
Main Results:
- A history of tonsillectomy was associated with decreased odds of HPV-SNC (OR 0.28).
- No other behavioral or clinical factors were linked to HPV-SNC or HPV-independent SNC.
- Seroprevalence of anti-HPV16 E6 was significantly higher in HPV-SNC cases compared to controls and HPV-independent SNC.
Conclusions:
- HPV-SNC has distinct serologic features but no clear behavioral risk factors.
- Tonsillectomy's protective association suggests lymphoid tissue involvement in HPV-SNC oncogenesis.
- Further research is needed to identify risk factors for HPV-independent SNC.
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