Related Experiment Video
Updated: Jan 31, 2026
09:40
Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
Published on: November 28, 2018
7.8K
Long Non-Coding RNA RAB11B-AS1 Suppresses Cervical Cancer Progression by Upregulating RPL26 Expression
Xuemin Gu1, Yuanyuan Yang1, Zhixia Zhang1
1Department of Obstetrics and Gynaecology, Shanghai Tongji Hospital of Tongji University, Tongji University School of Medicine, 200065 Shanghai, China.
Frontiers in Bioscience (Landmark Edition)
|January 29, 2026
Summary
The long non-coding RNA RAB11B-AS1 is downregulated in cervical cancer (CC) and suppresses tumor progression. It acts by upregulating RPL26, suggesting potential as a biomarker and therapeutic target for CC.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Cervical cancer (CC) is a major gynecological malignancy.
- The role of the long non-coding RNA (lncRNA) RAB11B-AS1 in CC is largely unknown.
Purpose of the Study:
- To investigate the expression and function of lncRNA RAB11B-AS1 in cervical cancer.
- To elucidate the molecular mechanisms underlying RAB11B-AS1's role in CC progression.
Main Methods:
- Analysis of TCGA data for lncRNA expression across cancer types.
- RNA in situ hybridization for validation in CC tissues.
- Transcriptomic, proteomic, and functional assays to determine lncRNA function.
- In vivo and in vitro experiments to assess effects on CC growth and progression.
Main Results:
- lncRNA RAB11B-AS1 is downregulated in CC and correlates with better patient prognosis.
- RAB11B-AS1 inhibits CC cell proliferation, migration, and invasion while promoting apoptosis.
- RAB11B-AS1 upregulates RPL26 expression, activating the p53 pathway and suppressing tumor growth.
- RPL26 is essential for the tumor-suppressive functions of RAB11B-AS1 in CC.
Conclusions:
- lncRNA RAB11B-AS1 suppresses cervical cancer progression via RPL26-mediated p53 pathway activation.
- RAB11B-AS1 holds potential as a diagnostic biomarker and therapeutic target for cervical cancer.
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
9.9K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.9K
02:39lncRNA - Long Non-coding RNAs
3.6K
3.6K
03:03mTOR Signaling and Cancer Progression
4.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
4.8K
02:35Chromatin Position Affects Gene Expression
24.8K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area.
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.8K
01:42What is Gene Expression?
196.6K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
196.6K
02:36RNA Polymerase II Accessory Proteins
11.0K
Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
11.0K