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Updated: Jan 31, 2026
12:24
Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes
Published on: June 3, 2014
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Influence of Coagulation Factor VIII on Ischemic Stroke
María Del Mar Martínez-Salmerón1, Laura Amaya-Pascasio1, Patricia Martínez-Sánchez1,2
1Department of Neurology, Torrecárdenas University Hospital, 04009 Almería, Spain.
Revista De Neurologia
|January 29, 2026
Summary
Elevated Factor VIII levels were common in ischemic stroke patients but not linked to cryptogenic stroke. Further research is needed to confirm Factor VIII
Area of Science:
- Neurology
- Hematology
- Thrombosis Research
Background:
- Cryptogenic stroke mechanisms are under investigation.
- Hypercoagulable states are studied as potential causes.
- Elevated Factor VIII is a suspected prothrombotic marker for ischemic stroke.
Purpose of the Study:
- To investigate the association between elevated Factor VIII levels and ischemic stroke.
- To determine if Factor VIII levels correlate with specific stroke etiological subtypes.
Main Methods:
- Retrospective observational study of 68 ischemic stroke patients (Oct 2018-Oct 2023).
- Factor VIII levels measured ≥3 months post-stroke; elevated defined as >150%.
- Stroke etiology, risk factors, and thrombophilia biomarkers were recorded and analyzed.
Main Results:
- Elevated Factor VIII (>150%) found in 41.2% of patients.
- No significant association between elevated Factor VIII and cryptogenic stroke (p=0.27).
- Weak correlation with antithrombin (p=0.039) and significant association with prior atrial fibrillation (p=0.04).
Conclusions:
- High Factor VIII levels were frequent but not associated with cryptogenic stroke in this cohort.
- Further large-scale studies are required to clarify independent associations with stroke subtypes.
- The role of Factor VIII as a secondary finding related to systemic factors needs investigation.
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