Related Experiment Video
Updated: Jan 31, 2026
13:21
Detection of Nitric Oxide and Superoxide Radical Anion by Electron Paramagnetic Resonance Spectroscopy from Cells using Spin Traps
Published on: August 18, 2012
19.5K
Core-Shell Type Nanoagent Enables Phototriggered Synergistic Antitumor Activity via Chlorine Radical-Induced and
Qun Li1, Weier Bao1, Xiangxiang Kong1
1School of Chemical Sciences, University of Chinese Academy of Sciences (UCAS), Beijing 100049, P. R. China.
ACS Applied Bio Materials
|January 29, 2026
Summary
A novel nanoagent, mSU@A-NPs@F-R, utilizes synergistic effects of chlorine radical (•Cl) and nitric oxide (NO) to enhance antitumor therapy. This nanoagent demonstrates significant efficacy in destroying cancer cells both in vitro and in vivo.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Cancer Therapy
Background:
- Chlorine radical (•Cl) shows potential for enhancing oxidative stress in antitumor therapy.
- Developing novel nanoagents is crucial for synergistic cancer treatment strategies.
Purpose of the Study:
- To develop a core-shell nanoagent (mSU@A-NPs@F-R) for cancer therapy.
- To leverage the synergistic effects of photogenerated chlorine radical (•Cl) and nitric oxide (NO).
Main Methods:
- Fabrication of mSU@A-NPs@F-R nanoagent using upconversion nanoparticles (UCNPs), AgCl nanoparticles, and l-arginine.
- Photoactivation via near-infrared (NIR) light to generate •Cl and Ag atoms.
- Ag atoms mediate NO release from l-arginine, while NO enhances •Cl generation.
Main Results:
- The nanoagent effectively generates both •Cl and NO upon NIR light irradiation.
- •Cl induces oxidative damage to DNA and mitochondria.
- NO stabilizes DNA damage and exacerbates mitochondrial injury, leading to synergistic cancer cell destruction.
- High therapeutic efficacy demonstrated in vitro and in vivo tumor models.
Conclusions:
- The developed mSU@A-NPs@F-R nanoagent offers a promising strategy for synergistic cancer therapy.
- The combined action of •Cl and NO provides enhanced antitumor effects.
- This approach holds potential for future clinical translation in cancer treatment.
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