A myeloma identity crisis yields daratumumab resistance

Cellular respiration produces 30 - 32 ATP per glucose molecule. Although most of the ATP results from oxidative phosphorylation and the electron transport chain (ETC), 4 ATP are gained beforehand (2 from glycolysis and 2 from the citric acid cycle).
The ETC is embedded in the inner mitochondrial membrane and is comprised of four main protein complexes and an ATP synthase. NADH and FADH2 pass electrons to these complexes, which pump protons into the intermembrane space. This distribution of...

The theoretical yield of a reaction is the amount of product estimated to form based on the stoichiometry of the balanced chemical equation. The theoretical yield assumes the complete conversion of the limiting reactant into the desired product. The amount of product that is obtained by performing the reaction is called the actual yield, and it may be less than or (very rarely) equal to the theoretical yield.

Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...

Double-angle and half-angle trigonometric identities are derived from the fundamental sum and difference formulas and serve as essential tools for simplifying expressions, solving equations, and evaluating integrals. These identities reduce the complexity of trigonometric functions by relating functions of a multiple or fractional angle to functions of a single angle. Their applications extend across mathematics, physics, and engineering, particularly in Fourier analysis, wave mechanics, and...

Social identity constitutes a significant aspect of an individual’s self-concept, shaped by membership in various social groups, including gender, nationality, ethnicity, sexual orientation, and political affiliation. Individuals associate specific traits with particular social groups, leading to internalization of these traits. For example, musicians are often perceived as creative, while women are frequently associated with nurturing tendencies. Once individuals identify with a...

Trigonometric identities are equations that relate trigonometric functions and hold for all angles within their domains. A fundamental identity among these is the Pythagorean identity, which arises directly from the geometry of the unit circle. For any angle θ, a point on the unit circle has coordinates (cos⁡ θ, sin ⁡θ), and since the radius of the circle is one, the Pythagorean Theorem gives:This identity serves as the basis for deriving additional identities.