Related Experiment Video
Updated: Jan 31, 2026
06:47
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
10.2K
Novel Therapeutic Strategies for Atopic Dermatitis: Biomarker Modulation and Clinical Implications. A Systematic
Noelia Moreiras-Arias1,2, Juan José Nieto-Fontarigo3,4, Francisco Javier Salgado5,6
1Department of Dermatology, Complexo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, 15706, Spain.
Clinical Reviews in Allergy & Immunology
|January 29, 2026
Summary
Innovative systemic therapies for atopic dermatitis (AD) effectively target key pathways, showing biomarker reductions like CCL17/TARC and LDH that correlate with clinical improvements. Further research aims for integrated biomarker panels for precision medicine.
Area of Science:
- Dermatology and Immunology
- Pharmacology
Background:
- Understanding of atopic dermatitis (AD) pathogenesis has advanced, leading to novel systemic therapies.
- Biologic agents and Janus kinase (JAK) inhibitors target specific immunologic pathways in AD.
Purpose of the Study:
- To systematically review evidence on systemic therapies' impact on AD biomarkers.
- To correlate biomarker changes with clinical outcomes in atopic dermatitis management.
Main Methods:
- Comprehensive literature search (2014-2024) across major databases.
- Inclusion of 80 studies investigating biologic agents, JAK inhibitors, and emerging AD treatments.
- Analysis of biomarker data (CCL17/TARC, LDH, IgE) and clinical scores (EASI, SCORAD).
Main Results:
- Consistent reductions in CCL17/TARC, LDH, and total IgE observed across drug classes.
- Biomarker changes generally paralleled clinical improvements in EASI and SCORAD scores.
- Transcriptomic, proteomic, and microbiome analyses indicated normalization of inflammatory signatures and improved skin barrier function.
Conclusions:
- CCL17 and LDH are reliable biomarkers for AD severity and treatment response, though specificity is limited.
- Heterogeneity in study designs hinders direct result comparison.
- Future research should focus on integrated biomarker panels for precision medicine in atopic dermatitis.
More Related Videos
Related Concept Videos
01:10Review and Preview
8.4K
In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
Percentiles are a type of fractile that partition data into...
8.4K
01:13Review and Preview
11.2K
Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.2K
01:20Random and Systematic Errors
14.9K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.9K
01:17Systematic Sampling Method
13.2K
Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
Systematic sampling is one of the simplest methods...
13.2K
01:10Propagation of Uncertainty from Systematic Error
1.5K
The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
1.5K
01:13Therapeutic Index
6.8K
The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.8K