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Updated: Jan 31, 2026

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Cerebral microbleed burden is associated with domain-specific cognitive impairment pattern in acute stroke

Yun-He Xia1, Xiao Hu1, Sun-Hong Yan1

  • 1Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

Neurological Research
|January 29, 2026
PubMed
Abstract

Insights

Cerebral microbleeds (CMBs) are linked to cognitive decline in stroke patients. Higher CMB burden, especially mixed and deep, correlates with impaired visuospatial, executive, and memory functions.

Area of Science:

  • Neurology
  • Neuroimaging
  • Cognitive Science

Background:

  • Cerebral microbleeds (CMBs) are indicators of cerebral small vessel disease (CSVD).
  • Cognitive impairment is common in acute stroke patients.
  • The relationship between CMB burden and specific cognitive deficits requires further investigation.

Purpose of the Study:

  • To investigate the association between CMB burden and domain-specific cognitive impairment in acute stroke patients.
  • To determine if CMB burden predicts cognitive deficits in stroke survivors.

Main Methods:

  • 163 acute stroke patients were enrolled and categorized by MoCA scores.
  • Demographic, clinical, laboratory, and neuroimaging data were collected.
  • Multivariable logistic and linear regression models were used to analyze data.

Main Results:

  • Older age, lower education, and higher CSVD burden were linked to cognitive impairment.
  • Total CMB number correlated inversely with visuospatial/executive function and memory recall.
  • Mixed CMBs were associated with visuospatial/executive deficits, and deep CMBs with abstract reasoning deficits.

Conclusions:

  • CMB burden, particularly mixed and deep distributions, is independently associated with specific cognitive domain impairments in acute stroke patients.
  • CMB assessment is important for cognitive risk stratification in stroke patients.
Keywords:
Cerebral microbleedscerebral small vessel diseasecognitive impairmentpost-stroke cognitive impairmentstroke

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