Patient-Reported Outcomes after Surgery for Proliferative Vitreoretinopathy: Post hoc Analysis of a Randomized...

Area of Science:

• Ophthalmology
• Retinal Diseases
• Surgical Outcomes

Background:

• Proliferative vitreoretinopathy (PVR) is a major cause of surgical failure in rhegmatogenous retinal detachment (RRD).
• PVR-RRD is associated with poor visual prognosis and impacts patient quality of life (QOL).

Purpose of the Study:

• To evaluate changes in vision-related QOL using the VFQ-25 and SF-36 tests after PVR-RRD surgery.
• To identify clinical and demographic factors associated with QOL recovery post-surgery.

Main Methods:

• Post-hoc analysis of a phase IIIb randomized clinical trial involving pars plana vitrectomy and silicone oil tamponade for PVR-RRD.
• VFQ-25 and SF-36 assessments at baseline, 6 months, and 12 months postoperatively.
• Statistical analyses included descriptive statistics, non-parametric tests, and Spearman correlation.

Main Results:

• Significant improvements in VFQ-25 (p=0.0004) and SF-36 (p=0.006) total scores were observed 12 months post-surgery.
• Psychosocial domains showed the largest improvements: VFQ-25 mental health (p=3.35×10⁻⁵) and SF-36 mental health (p=2.38×10⁻⁶).
• Worse final best-corrected visual acuity (BCVA) correlated with lower QOL scores; baseline QOL and final BCVA influenced perceived recovery more than anatomical success or surgery count.

Conclusions:

• Surgery for PVR-RRD leads to significant improvements in visual function and general QOL, primarily driven by psychosocial recovery.
• Personalized care and rehabilitation are crucial for managing PVR-RRD patients.
• Final BCVA and baseline QOL are key predictors of patient-reported recovery outcomes.