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Related Experiment Video

Updated: Jan 31, 2026

Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage

Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage

Published on: May 6, 2020

From sequence to function: Bridging single-molecule kinetics and molecular diversity.

A N Kapanidis^1,2, L Muras³, K Sreenivasa⁴

¹Department of Physics, University of Oxford, Oxford, UK.

Science (New York, N.Y.)

|January 29, 2026

Summary

This summary is machine-generated.

New single-molecule techniques enable large-scale analysis of nucleic acid and protein sequences. These methods link molecular sequence, structure, dynamics, and function, advancing drug discovery and genomics.

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Last Updated: Jan 31, 2026

Parallel High Throughput Single Molecule Kinetic Assay for Site-Specific DNA Cleavage

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Area of Science:

Molecular Biology
Biophysics
Genomics

Background:

Biological function is dictated by nucleic acid and protein sequences.
Nucleic acids possess physicochemical properties influencing structure, dynamics, and interactions.
Understanding sequence-property relationships requires methods capturing molecular diversity and dynamics.

Purpose of the Study:

To explore advanced single-molecule techniques for analyzing molecular dynamics at scale.
To bridge the gap between molecular sequence, structure, dynamics, and biological function.

Main Methods:

Utilizing highly multiplexed single-molecule approaches.
Observing molecular dynamics across millions of individual molecules and thousands of sequences.
Developing scalable methods for analyzing sequence-dependent energetic landscapes.

Main Results:

Demonstrated ability to observe molecular dynamics across a vast number of molecules and sequences.
Initiated the integration of sequence, structure, dynamics, and function analysis at scale.
Showcased the potential of these advanced techniques in various biological applications.

Conclusions:

Highly multiplexed single-molecule methods are revolutionizing the study of sequence-function relationships.
These techniques offer unprecedented opportunities for drug discovery, molecular diagnostics, and functional genomics.
Ongoing development promises further advancements in understanding molecular behavior at scale.