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Updated: Jan 31, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Sequential Polychloromethylation/Cyclization of N-Cyanamide Alkenes for the Construction of
Fei Meng1, Hongbin Zou1, Yang Zhen1
1Institute of Pesticide, College of Plant Protection, Yangzhou University, Yangzhou 225009, China.
Abstract:
A green and efficient radical cascade cyclization method for the synthesis of polychloromethyl-substituted quinazolinones is reported. The polychloromethylation/cyclization process proceeds in 64-93% yields using unactivated alkenes and is characterized by its metal-free conditions, broad substrate scope, and excellent functional group compatibility. This strategy is also applicable to other polyhaloalkanes, offering promising potential for the preparation of pharmaceutically relevant polychloromethyl-substituted N-heterocycles.
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