Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atomic Force Microscopy01:08

Atomic Force Microscopy

4.5K
Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
4.5K
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

217
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
217
Nuclear Stability03:18

Nuclear Stability

23.2K
Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.2K
Harmonic Mean01:09

Harmonic Mean

3.7K
The arithmetic mean is usually skewed towards the larger values in the data set. Therefore, to avoid this inherent bias towards smaller values, the harmonic mean is used.
Take the example of the speed of a car, which is the measure of the rate of distance traveled. If the vehicle traverses the same distance back-and-forth, its average speed equals the total distance traveled divided by the total time taken. However, if the car moves with varying speeds, then the arithmetic mean is more skewed...
3.7K
Intermolecular vs Intramolecular Forces03:00

Intermolecular vs Intramolecular Forces

96.8K
Intermolecular forces (IMF) are electrostatic attractions arising from charge-charge interactions between molecules. The strength of the intermolecular force is influenced by the distance of separation between molecules. The forces significantly affect the interactions in solids and liquids, where the molecules are close together. In gases, IMFs become important only under high-pressure conditions (due to the proximity of gas molecules). Intermolecular forces dictate the physical properties of...
96.8K
Atomic Orbitals02:44

Atomic Orbitals

43.9K
An atomic orbital represents the three-dimensional regions in an atom where an electron has the highest probability to reside. The radial distribution function indicates the total probability of finding an electron within the thin shell at a distance r from the nucleus. The atomic orbitals have distinct shapes which are determined by l, the angular momentum quantum number. The orbitals are often drawn with a boundary surface, enclosing densest regions of the cloud.
43.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cyclam-based Cu(II) and Fe(III) complexes for antifouling coating development.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Sleep Habits, Physical Exercise, and Social Media Use and Their Influence on Perceptions of Physical and Mental Health-Case Study at a Higher Education Institution in Portugal.

Healthcare (Basel, Switzerland)·2026
Same author

Sacsin deletion decreases cell viscoelasticity and motility in a glial cell model of autosomal recessive spastic ataxia of Charlevoix Saguenay.

Archives of biochemistry and biophysics·2025
Same author

New Cyclam-Based Fe(III) Complexes Coatings Targeting <i>Cobetia marina</i> Biofilms.

Molecules (Basel, Switzerland)·2025
Same author

Functional characterization reveals the importance of Arabidopsis ECA4 and EPSIN3 in clathrin mediated endocytosis and wall structure in apical growing cells.

The New phytologist·2024
Same author

Morphological and Biophysical Study of S100A9 Protein Fibrils by Atomic Force Microscopy Imaging and Nanomechanical Analysis.

Biomolecules·2024

Related Experiment Video

Updated: Jan 31, 2026

Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy
09:20

Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy

Published on: October 4, 2010

11.7K

Enhancing atomic force microscopy stability through second harmonic optical fibre cavity control.

Joana Nobre1, Tiago Cordeiro1, Tiago T Robalo1

  • 1Departamento de Física, Faculdade de Ciências, Universidade de Lisboa, Campo Grande 16, 1749-016 Lisbon, Portugal; BioISI-Biosystems and Integrative Sciences Institute, Faculdade de Ciências, Universidade de Lisboa, Campo Grande 16, 1749-016 Lisbon, Portugal.

Ultramicroscopy
|January 29, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed a new method to directly measure interatomic potentials by controlling tip-sample distance. This technique overcomes limitations of conventional atomic force microscopy, enabling precise force measurements.

Keywords:
AFMInteratomic potentialInterferometricNanoscale

More Related Videos

Bacterial Immobilization for Imaging by Atomic Force Microscopy
10:03

Bacterial Immobilization for Imaging by Atomic Force Microscopy

Published on: August 10, 2011

17.8K
Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
10:15

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

Published on: July 22, 2015

15.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy
09:20

Live Cell Response to Mechanical Stimulation Studied by Integrated Optical and Atomic Force Microscopy

Published on: October 4, 2010

11.7K
Bacterial Immobilization for Imaging by Atomic Force Microscopy
10:03

Bacterial Immobilization for Imaging by Atomic Force Microscopy

Published on: August 10, 2011

17.8K
Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers
10:15

Atomic Force Microscopy Imaging and Force Spectroscopy of Supported Lipid Bilayers

Published on: July 22, 2015

15.4K

Area of Science:

  • Materials Science
  • Surface Physics
  • Nanotechnology

Background:

  • Interatomic potentials govern material properties.
  • Conventional atomic force microscopy (AFM) struggles to directly measure tip-sample interactions due to limited distance control.
  • Existing methods often measure deflection versus displacement, not direct force-distance relationships.

Purpose of the Study:

  • To propose and demonstrate a novel methodology for directly measuring tip-surface interactions as a function of tip-sample distance.
  • To overcome the limitations of conventional AFM in quantifying interatomic potentials.
  • To provide a more accurate approach for characterizing forces at the nanoscale.

Main Methods:

  • Utilizing an AC interferometer to precisely monitor absolute tip displacement.
  • Implementing a negative feedback loop to maintain constant tip position by adjusting the cantilever anchoring point.
  • Actively controlling the tip-sample distance to a point of maximum interferometer sensitivity.

Main Results:

  • Direct measurement of tip-surface interactions as a function of tip-sample distance.
  • Successful prevention of tip-jump-to-contact phenomena, ensuring stable measurements.
  • Accurate determination of indentation depth through sample motion tracking.

Conclusions:

  • The proposed methodology offers a direct and accurate way to measure interatomic potentials.
  • This technique enhances the capabilities of force microscopy by providing precise distance control.
  • The findings pave the way for improved characterization of material properties at the atomic scale.