Related Experiment Video

Updated: Jan 31, 2026

Focal Cerebral Ischemia Model by Endovascular Suture Occlusion of the Middle Cerebral Artery in the Rat
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Evaluating long-term outcomes of endovascular revascularization in symptomatic chronic internal carotid artery

Xiaoliang Yin1, Xiaodong Chen1, Jiachun Liu2

  • 1Department of Neurosurgery, Peking University Third Hospital, Peking University, Beijing, Haidian 100191, China.

Clinical Neurology and Neurosurgery
|January 29, 2026
PubMed

Insights

Successful endovascular revascularization significantly reduces recurrent stroke risk in chronic internal carotid artery occlusion patients. Failure to revascularize is linked to higher event rates, highlighting the therapy's potential benefit.

Area of Science:

  • Vascular Neurology
  • Interventional Cardiology
  • Neurosurgery

Background:

  • Chronic internal carotid artery occlusion (CICAO) is a significant stroke risk factor.
  • Endovascular revascularization is a potential treatment, but its real-world effectiveness is not well-established.
  • Symptomatic CICAO patients refractory to medical therapy require evaluation of advanced treatment options.

Purpose of the Study:

  • To evaluate the effectiveness and safety of endovascular revascularization in symptomatic CICAO patients.
  • To assess long-term outcomes following endovascular revascularization for CICAO.
  • To identify risk factors associated with poor outcomes in CICAO patients undergoing revascularization.

Main Methods:

  • Retrospective cohort study of CICAO patients undergoing endovascular revascularization.
  • Patients grouped by revascularization success or failure.
  • Logistic multivariate analysis and COX proportional hazard regression used to identify risk factors and compare outcomes.

Main Results:

  • Successful revascularization achieved in 75.81% of 62 procedures across 59 patients.
  • Perioperative complication rate was 6.45%.
  • Successful revascularization group had significantly lower primary (6.52% vs. 23.08%) and total endpoint event rates.

Conclusions:

  • Successful endovascular revascularization is associated with a lower incidence of cerebrovascular events in CICAO patients.
  • Revascularization failure may increase the risk of recurrent events.
  • Results suggest a potential benefit of endovascular revascularization, but caution is advised due to sample size.
Abstract

Keywords:
Carotid Artery StentingChronic internal carotid artery occlusionIschemic Strokeendovascular revascularization

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