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Updated: Jan 31, 2026
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Equivalence of the Peripheral Common Trunk and Adrenal Central Vein in Left Adrenal Vein Sampling
Yuhai Zhang1, Meihui Huang2, Jingwen Yu1
1Department of Endocrinology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, China.
Purpose:
To compare 3 left adrenal vein sampling (AVS) sites-the left adrenal central vein (LCV), the peripheral common trunk (P-CMT), which is near the confluence of the inferior phrenic vein and LCV, and the middle common trunk (M-CMT)-and attempt to identify the reliable site for left AVS.
Materials And Methods:
Consecutive patients with primary aldosteronism who underwent AVS at a general hospital (September 2019 to October 2023) were enrolled. Procedure details and clinical data were collected to analyze the success rates of blood sampling (selectivity index [SI] ≥ 2), aldosterone-to-cortisol (A/C) ratios, and bilateral suppression characteristics.
Results:
Among the 155 enrolled patients (90 men), both LCV and P-CMT had higher cortisol levels, SI, and success rates than M-CMT (P < .05). No meaningful differences were observed between LCV and P-CMT. In the 126 patients with successful sampling, LCV had higher cortisol levels than P-CMT, but no significant difference was observed in plasma aldosterone concentration (PAC), A/C ratios, and lateralization index (LI). LI cutoffs (≥2 or ≥4) showed no difference in dominant side determination. Pearson analysis confirmed strong correlations in plasma cortisol, PAC, and LI between LCV and P-CMT. Apparent bilateral adrenal suppression rates did not differ significantly between P-CMT and LCV.
Conclusions:
The P-CMT is a valid and practical alternative to the LCV for successful left AVS.
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