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Advancing Prostate Cancer Diagnostics: The Potential of Paper-Based Biosensors for Point-of-Care Testing.

Wei Yin Lim1, Wee Jian Chin2, Gopinath Packirisamy3

  • 1Micro and Nano Devices Laboratory, Department of Electrical and Robotics Engineering, Electrical and Computer Systems Engineering, School of Engineering, Monash University Malaysia, Bandar Sunway 47500, Selangor, Malaysia; Department of Pharmacology, Faculty of Medicine, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.

Clinica Chimica Acta; International Journal of Clinical Chemistry
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PubMed
Summary

Novel paper-based biosensors offer a promising, cost-effective approach for early prostate cancer detection. Advanced materials enhance sensitivity and specificity, aiming to overcome limitations of the prostate-specific antigen (PSA) test for improved patient outcomes.

Keywords:
BiomarkersBiosensorEmerging biomarkersPaper-based sensorPoint-of-care testingProstate cancer

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Diagnostics

Background:

  • Prostate cancer is a leading cause of cancer death globally, necessitating improved early detection methods.
  • Current prostate-specific antigen (PSA) screening has limitations in specificity, leading to unnecessary procedures and missed diagnoses.
  • There is a critical need for sensitive and specific biomarkers and diagnostic tools beyond PSA.

Purpose of the Study:

  • To review recent advancements in biosensor platforms for prostate cancer detection.
  • To highlight the potential of advanced materials, particularly in paper-based biosensors, for enhanced diagnostic performance.
  • To discuss challenges and opportunities for clinical translation of these novel biosensors.

Main Methods:

  • Review of current literature on biosensor technology for prostate cancer.
  • Focus on paper-based biosensors, nanomaterials, and surface modification strategies.
  • Analysis of biomarker discovery and analytical performance enhancement.

Main Results:

  • Paper-based biosensors show significant promise for rapid, cost-effective, and portable point-of-care (POC) prostate cancer testing.
  • Integration of nanomaterials and advanced surface modifications improves sensitivity, specificity, and stability.
  • Emerging biomarkers and improved biosensor designs offer potential to surpass PSA test performance.

Conclusions:

  • Paper-based biosensors, empowered by advanced materials, represent a significant advancement in prostate cancer diagnostics.
  • Further research and development are crucial to address challenges hindering clinical translation and widespread adoption.
  • These technologies hold the potential to revolutionize early prostate cancer detection and monitoring.